What Is 2,5-Dihydroxybenzoyl Dipeptide-27?
2,5-Dihydroxybenzoyl Dipeptide-27 is a lab-crafted molecule formed when 2,5-dihydroxybenzoic acid is linked to a short two-amino-acid chain known as Dipeptide-27. The resulting hybrid combines the water-loving character of a small peptide with the antioxidant-rich backbone of the benzoic acid derivative, creating a multitasking cosmetic ingredient.
Although peptides and benzoic acid derivatives have been used separately in beauty products for decades, researchers began blending the two in the early 2010s to get the best of both worlds: the skin-friendly signaling benefits of peptides plus the moisture-binding and protective traits of phenolic acids. This specific compound emerged from that wave of innovation and has since been adopted by suppliers specializing in high-performance actives.
Manufacturing typically starts with fermenting or synthetically producing 2,5-dihydroxybenzoic acid, then activating its carboxyl group so it can bond to Dipeptide-27 under controlled pH and temperature. The finished material is purified, dried and standardized into a water-soluble powder or liquid concentrate for formulators.
Because it is gentle, versatile and effective at low doses, you will most often see 2,5-Dihydroxybenzoyl Dipeptide-27 in leave-on products such as anti-aging serums, daily moisturizers, hydrating masks, eye creams and barrier-supporting treatments that aim to keep skin supple and resilient.
2,5-Dihydroxybenzoyl Dipeptide-27’s Cosmetic Benefits/Uses
This ingredient delivers several complementary actions that help skin look and feel healthier.
- Humectant: Attracts and binds water from the environment and deeper skin layers, boosting surface hydration so skin appears plumper and smoother
- Skin Conditioning: Offers a soft, silky after-feel while supporting the natural moisture barrier, which can enhance overall texture and comfort
- Emollient: Fills in microscopic gaps between skin cells, creating a softer touch and reducing roughness or flakiness
- Skin Protecting: Forms a light protective film that helps shield against everyday environmental stressors like dry air and pollution
Who Can Use 2,5-Dihydroxybenzoyl Dipeptide-27?
This multitasking peptide suits nearly every skin type. Its water-binding nature helps dry or mature skin hold on to moisture, while its feather-light texture will not overwhelm oily or combination complexions. Sensitive skin generally tolerates it well because it is nonacidic and used at low concentrations, though anyone prone to reactivity should still keep an eye on how their skin feels in case of individual intolerance.
The ingredient is produced synthetically from laboratory-made amino acids and benzoic acid derivatives, not from animal tissue, so it is typically considered vegan and vegetarian friendly. Always check the full ingredient list of the finished product for any non-vegan additives such as beeswax or milk derivatives if that is a concern.
No data suggest that 2,5-Dihydroxybenzoyl Dipeptide-27 poses a special risk during pregnancy or breastfeeding. It is not known to penetrate deeply or disrupt hormones, but this is not medical advice. Expectant or nursing mothers should review any skincare routine with their doctor for personal guidance.
The molecule does not absorb UV light and is not known to increase photosensitivity, so daytime use is fine as long as you follow normal sun protection habits.
Potential Side Effects/Adverse Reactions
Responses to topical 2,5-Dihydroxybenzoyl Dipeptide-27 can differ from one person to the next. The issues listed below are possible yet uncommon when the ingredient is properly formulated and used as directed.
- Mild redness or stinging especially on very sensitive or compromised skin
- Temporary itching during the first few uses as skin adjusts to a new formula
- Contact dermatitis in rare cases where an allergy to the peptide or other formulation components exists
- Breakouts if the overall product contains occlusive or pore-clogging ingredients that do not suit acne-prone skin
If you develop persistent irritation, stop using the product and consult a healthcare professional or dermatologist for advice.
Comedogenic Rating
Rating: 0 / 5
2,5-Dihydroxybenzoyl Dipeptide-27 is water soluble and contains no heavy oils, waxes or fatty alcohols that typically clog pores. Its small molecular size lets it sit lightly on the skin and rinse away easily, so it earns a solid non-comedogenic score of 0.
That makes it compatible with acne-prone or breakout-prone skin types, provided the rest of the formula is also low in pore-clogging ingredients.
Keep in mind overall pore-friendliness depends on the finished product. Even a non-comedogenic active can become problematic if blended with thick butters or high-level silicones.
Summary
2,5-Dihydroxybenzoyl Dipeptide-27 works as a humectant, emollient, skin-conditioning and skin-protecting agent. Its peptide segment draws and holds water while the benzoic acid portion helps form a lightweight surface film that smooths texture and shields against daily stress. Together they plump the skin, soften rough patches and support the moisture barrier.
Although not yet a household name, the ingredient is gaining traction in mid-range and premium serums that highlight peptide technology and clean, water-based formulas.
Current safety data show a low risk of irritation or pore blockage when used at typical cosmetic levels, making it suitable for most users. As with any new skincare product, run a quick patch test first to ensure your skin agrees with it.