What Is 2-Mercaptonicotinoyl Glycine?
2-Mercaptonicotinoyl Glycine is a lab-made molecule that joins parts of vitamin B3 with the amino acid glycine and a sulfur group. Chemists first explored it while looking for gentle skin smoothers in the early 2000s, then it moved into test batches of face creams where it showed promise as a skin conditioner. Production starts with nicotinic acid, which is reacted step by step with sulfur-containing agents and glycine under controlled heat, then purified into a fine powder. Because it is stable in water-based formulas and works well at skin-friendly pH levels, brands add it to light lotions, daily moisturizers, hydrating serums, sheet masks and leave-on anti-aging treatments.
2-Mercaptonicotinoyl Glycine’s Cosmetic Benefits/Uses
This ingredient is prized for its skin-conditioning talent. By helping the outer layer of skin hold on to water and by supporting a smoother surface, it leaves skin feeling softer, looking more even and better able to take in follow-up products.
Who Can Use 2-Mercaptonicotinoyl Glycine
This ingredient suits most skin types, including dry, normal, combination and oily, because it is water soluble and light. Sensitive skin usually tolerates it as it has a low risk of stinging or clogging, yet very reactive skin may still want to introduce it slowly since any new active can sometimes provoke redness.
2-Mercaptonicotinoyl Glycine is synthesized entirely from non-animal sources, so it is considered vegan and vegetarian friendly. No animal by-products are involved in either its raw materials or its production steps.
Current safety data shows no specific concern for pregnant or breastfeeding women when the ingredient is used in a leave-on cosmetic. This is not medical advice and anyone who is pregnant or nursing should check with a doctor before adding new skincare products, just to be safe.
The molecule does not absorb UV light in a way that would increase sun sensitivity, so it is not known to cause photosensitivity. Regular daytime sunscreen use is still recommended as part of any good routine.
Potential Side Effects/Adverse Reactions
Reactions to topical 2-Mercaptonicotinoyl Glycine differ from person to person. The following is a list of potential side effects that could occur even though most users experience none when the ingredient is formulated and used correctly.
- Mild redness or warmth brief flushing in areas where the product is applied
- Dryness or tightness usually if the product is layered with strong exfoliating acids or retinoids
- Itching especially on very sensitive or compromised skin barriers
- Contact dermatitis rare allergic reaction more likely in individuals sensitive to sulfur containing compounds
- Eye irritation if the product migrates into the eye area
If any of these side effects occur discontinue use and seek medical advice if symptoms persist or worsen
Comedogenic Rating
Rating: 0–1 (very low)
2-Mercaptonicotinoyl Glycine dissolves in water rather than oil, is used at small percentages and does not form a heavy film on skin, so it rarely blocks pores.
That makes it a good option for people who are prone to acne or frequent breakouts.
It also shows no evidence of feeding Malassezia yeast, so users worried about fungal acne can generally consider it low risk.
Summary
2-Mercaptonicotinoyl Glycine is a modern skin-conditioning molecule that boosts moisture retention and smooths texture by blending niacin inspired activity with hydrating glycine and a sulfur link that supports gentle surface renewal.
The ingredient is still somewhat niche, popping up in select creams, serums and sheet masks rather than dominating shelves, yet its lightweight feel and promising results are winning it a quiet following.
Safety data rate it as low concern with minimal irritation potential and virtually no comedogenicity, but it is always smart to patch test any new product to be sure your own skin is happy.