What Is 3,4-Dihydroxybenzoyl Dipeptide-49 Amide?
3,4-Dihydroxybenzoyl Dipeptide-49 Amide is a lab-created molecule formed when 3,4-dihydroxybenzoic acid is chemically joined to a tiny two-amino-acid chain called dipeptide-49, with the peptide’s tail converted to an amide. The union pairs the antioxidant power of a plant-derived phenolic acid with the skin-friendly profile of a peptide, producing a stable ingredient that dissolves in water and works well at skin-friendly pH levels. Peptide technology gained traction in the early 2000s as brands searched for gentler options to support the skin barrier, and formulators soon discovered that coupling certain peptides with phenolic acids boosted their ability to attract water and calm the skin surface. Today the compound is manufactured through controlled synthesis in GMP facilities, followed by purification to cosmetic grade. You are most likely to see it in lightweight serums, daily moisturizers, hydrating masks, soothing after-sun gels and premium anti-aging creams where long-lasting moisture and skin barrier support are key selling points.
3,4-Dihydroxybenzoyl Dipeptide-49 Amide’s Cosmetic Benefits/Uses
In formulas this multitasking ingredient brings four key benefits
- Humectant: pulls water from the air and deeper skin layers to the surface, keeping the complexion looking plump and reducing the appearance of fine lines
- Skin conditioning: softens rough patches and improves overall texture so skin feels smoother and more supple
- Emollient: fills microscopic gaps between skin cells, creating a quick silky finish that helps lock in hydration
- Skin protecting: forms a light breathable film that shields the skin from everyday environmental stress like wind or dry indoor air
Who Can Use 3,4-Dihydroxybenzoyl Dipeptide-49 Amide
This ingredient is gentle and water based so it suits nearly every skin type including dry, normal, combination, oily and even sensitive skin that reacts to harsher actives. Because it is lightweight and not greasy those with very oily or acne prone skin usually tolerate it without feeling heavy or occlusive. There are no known concerns for darker skin tones or rosacea either.
The molecule is produced via laboratory synthesis using amino acids that are not sourced from animals, making it appropriate for vegans and vegetarians as long as the finished product also follows cruelty free and animal origin guidelines.
No safety warnings have been issued for pregnancy or breastfeeding because the peptide is large and stays on the skin surface, however research in this area is limited. This is not medical advice and anyone who is pregnant or nursing should show the full ingredient list to a qualified healthcare professional before adding a new product.
3,4-Dihydroxybenzoyl Dipeptide-49 Amide does not make skin more sensitive to sunlight and can be used morning or night, though daily SPF is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical use of 3,4-Dihydroxybenzoyl Dipeptide-49 Amide vary from person to person. The points below list potential reactions but most users will not experience them when the ingredient is properly formulated and used as directed.
- Mild redness or warmth shortly after application
- Temporary stinging on very compromised or freshly exfoliated skin
- Itching or small rash in people with a specific allergy to phenolic acids or peptides
- Hives or swelling in rare cases of severe hypersensitivity
- Increased dryness if layered with strong exfoliating acids or high dose retinoids
If any persistent irritation or allergic reaction occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5. 3,4-Dihydroxybenzoyl Dipeptide-49 Amide is a small, water-soluble peptide that does not form heavy films or clog follicular openings. It lacks oily carriers and is typically used at low concentrations so the risk of pore blockage is negligible. This makes it suitable for acne-prone or breakout-prone skin types. Because the molecule is hydrophilic it easily rinses away during cleansing and does not build up over time, further lowering its comedogenic potential.
No published data suggest it interacts with sebum oxidation or bacterial growth, two other pathways that can worsen acne, so its presence in a formula should not worsen blemishes unless other comedogenic ingredients are also included.
Summary
3,4-Dihydroxybenzoyl Dipeptide-49 Amide acts as a humectant, skin conditioner, emollient and light skin protectant. Its phenolic acid half binds water and offers antioxidant support while the peptide half lays down a silky surface layer that smooths rough patches and helps keep moisture locked in. Together these actions leave skin feeling hydrated, soft and resilient.
The ingredient is still a niche addition so you will mainly spot it in higher-end serums and creams targeting dehydration relief and barrier support rather than in mass-market lines. As safety data accumulate its use could expand into more everyday products.
Overall it is considered low risk for irritation or clogged pores when formulated correctly. As with any new skincare ingredient perform a patch test before full application to rule out personal sensitivities.