What Is Acetyl Dipeptide-31 Amide?
Acetyl Dipeptide-31 Amide is a lab crafted peptide derived from Dipeptide-31 that has been acetylated and finished with an amide group at one end. This slight tweak in its structure helps improve stability and compatibility with skin care formulas. Peptides in general are short chains of amino acids that can signal or support various skin functions, and this particular one was developed during the early 2000s when cosmetic chemists began exploring bioactive peptides for gentler anti-aging solutions. Commercial production starts with the controlled synthesis of Dipeptide-31 from individual amino acids, followed by an acetylation step that shields the peptide, then an amidation step that reduces its acidity, making it calmer on skin. The finished ingredient appears as a fine powder that dissolves readily in water-based solutions, which makes it easy to add late in the manufacturing process to prevent heat damage. You will most often spot Acetyl Dipeptide-31 Amide in lightweight serums, firming creams, eye treatments, sheet masks and other leave-on products that focus on skin comfort and resilience.
Acetyl Dipeptide-31 Amide’s Cosmetic Benefits/Uses
Its core role in a formula is simple yet valuable.
Skin conditioning: Acetyl Dipeptide-31 Amide helps keep the skin surface feeling soft smooth and supple. By supporting the skin’s natural barrier it can reduce the look of dryness and improve overall texture which is why formulators reach for it in products aimed at boosting comfort and a healthy appearance.
Who Can Use Acetyl Dipeptide-31 Amide
Because it is a gentle water-soluble peptide, Acetyl Dipeptide-31 Amide is generally suitable for all skin types including dry, oily, combination and sensitive skin. Its barrier-supporting nature makes it especially appealing to anyone dealing with tightness or rough texture. There are no specific skin types that must avoid it, though extremely reactive or allergy-prone individuals should always stay alert to any new ingredient.
The peptide is produced synthetically from basic amino acids without animal-derived materials, which means products featuring it are usually appropriate for vegans and vegetarians. Brands may still differ in their overall sourcing, so checking for a clear vegan label remains a good idea.
No studies have flagged concerns for pregnant or breastfeeding women when Acetyl Dipeptide-31 Amide is applied topically in cosmetic amounts. That said, this information is not medical advice. Anyone who is pregnant or nursing should review every skincare product with their doctor to be on the safe side.
The ingredient is not known to increase photosensitivity, so it does not make skin more vulnerable to sunburn. Standard daytime sun protection habits are still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical use of Acetyl Dipeptide-31 Amide can vary from person to person. The points below outline potential issues, but they are uncommon when the ingredient is formulated and used correctly.
- Mild redness or warmth
- Transient stinging or tingling on very sensitive skin
- Allergic contact dermatitis in individuals already sensitized to peptides or specific formulation excipients
- Breakouts if the finished product contains heavy occlusives that trap oil on acne-prone skin
If any of these effects occur, stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 / 5
Acetyl Dipeptide-31 Amide is water soluble, lightweight and used at very low concentrations so it does not sit in pores or form a heavy film that could trap sebum. For these reasons it carries virtually no risk of clogging pores on its own.
Suitable for acne-prone and breakout-prone skin.
Keep in mind that the finished product’s full formula matters; thick butters, oils or waxes paired with the peptide could still trigger congestion on some skin types.
Summary
Acetyl Dipeptide-31 Amide is a lab designed peptide that conditions skin by supporting barrier function which helps it feel soft smooth and resilient. It dissolves easily in water based formulas, works at low doses and plays nicely with other common actives.
It is not as famous as peptides like Matrixyl or copper peptides, yet it is quietly gaining traction in niche serums, eye gels and soothing creams aimed at comfortable healthy looking skin.
Current evidence shows it is very safe for topical use with minimal reports of irritation or pore clogging. As with any new skincare ingredient a small patch test is a smart way to rule out personal sensitivity before full use.