What Is Acetyl S-Carrot Tetrapeptide-1 Amide?
Acetyl S-Carrot Tetrapeptide-1 Amide is a lab-grown fragment of a natural carrot protein called phytosulfokine. Chemists start with the exact order of four amino acids— isoleucine, threonine and two tyrosines— then attach an acetyl group to the front and turn the tail end into an amide to make the molecule more stable on skin. This tiny piece of the larger plant protein was first explored by biotech researchers looking for plant-based peptides that could comfort and revive stressed skin. As peptide science moved into beauty labs in the early 2000s, brands adopted this carrot-inspired version for its gentle, skin-friendly profile.
The ingredient is produced through solid-phase peptide synthesis, a method that builds the amino acid chain one unit at a time. Because the process happens in a controlled environment the final material is free of plant allergens and pesticides. Once purified the peptide is blended into a protective solution or delivered as a dry powder for formulators.
You will usually spot Acetyl S-Carrot Tetrapeptide-1 Amide in leave-on products where its skin-conditioning talent can shine. Common formats include lightweight serums, hydrating creams, overnight masks, eye treatments and soothing after-sun lotions.
Acetyl S-Carrot Tetrapeptide-1 Amide’s Cosmetic Benefits/Uses
This carrot-derived peptide serves one main purpose in skincare.
Skin conditioning: It helps the upper layers of skin hold on to water, leaving the surface smoother and more supple. A stronger moisture barrier can also make skin look plumper and feel less rough which is why the peptide often appears in formulas aimed at calming dryness and supporting a healthy glow.
Who Can Use Acetyl S-Carrot Tetrapeptide-1 Amide
This peptide is generally suitable for all skin types including dry, oily, combination and sensitive because it is mild and free of fragrance or common allergens. People with easily irritated skin appreciate that it helps reinforce the moisture barrier rather than strip it.
The ingredient is made entirely in a lab with no animal inputs so it fits vegan and vegetarian lifestyles.
Current data shows no specific concerns for women who are pregnant or breastfeeding. As with any skincare during this life stage, this is not medical advice and it is best to review any product containing the peptide with a healthcare professional first to be extra safe.
Acetyl S-Carrot Tetrapeptide-1 Amide does not make skin more sensitive to sunlight so it is not considered photosensitising. Daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical use of Acetyl S-Carrot Tetrapeptide-1 Amide vary from person to person. The points below list potential side effects that are unlikely for most users when the ingredient is correctly formulated.
- Mild redness or warmth shortly after application
- Transient itching or tingling
- Localised rash in individuals with extreme peptide sensitivity
- Stinging if applied on cracked or broken skin
- Interaction with other formula components such as high levels of alcohol leading to dryness
If any uncomfortable reaction occurs discontinue use and consult a healthcare professional
Comedogenic Rating
Rating: 0 (non-comedogenic)
Acetyl S-Carrot Tetrapeptide-1 Amide is a tiny, water-soluble peptide with no oily or waxy carriers so it does not linger in pores or create the kind of film that can trap dead skin cells. It is typically used at very low concentrations and is easily rinsed away by the skin’s natural turnover. For these reasons formulators consider it non-comedogenic.
This makes the ingredient suitable for people who are prone to acne or frequent breakouts. If it appears in a breakout-triggering product, the culprit is more likely another component such as heavy oils or certain silicones rather than the peptide itself.
Because the raw material has no comedogenic footprint, its rating can shift only if it is paired with pore-clogging delivery systems like thick butters or occlusive waxes.
Summary
Acetyl S-Carrot Tetrapeptide-1 Amide is a lab crafted slice of a carrot protein that acts as a skin conditioner. By helping the outer layers hold moisture it leaves skin smoother, more elastic and better protected against daily stress. The peptide is still a niche addition in skincare, showing up mainly in higher-end serums and calming creams rather than mass market lines, yet its gentle nature is earning it steady attention from formulators looking for plant-inspired actives.
Safety data and real-world use point to a low risk of irritation or pore blockage, making the ingredient friendly for most skin types including sensitive and acne prone. As with any new skincare product it is wise to do a quick patch test before full use to be sure it agrees with your individual skin