What Is Aminolevulinoyl Tripeptide-35?
Aminolevulinoyl Tripeptide-35 is a lab-engineered peptide created by linking aminolevulinic acid, a naturally occurring compound involved in cell metabolism, with a short chain of three amino acids known as Tripeptide-35. The union of these two parts gives the ingredient a balanced profile of stability and skin affinity, making it attractive for modern cosmetic formulas. First explored in dermatology research for its light-responsive properties, scientists soon noticed its gentle brightening and conditioning effects, leading to its entry into skincare and hair care products during the past decade.
To make Aminolevulinoyl Tripeptide-35, chemists start with purified aminolevulinic acid harvested from fermentation of plant sugars. They then synthesize Tripeptide-35 through solid-phase peptide chemistry and unite the two components using controlled coupling reactions. The resulting compound is filtered, dried and tested for purity before being shipped to cosmetic manufacturers.
You will commonly find Aminolevulinoyl Tripeptide-35 in brightening serums, anti-aging creams, sheet masks, leave-on conditioners and targeted spot treatments. Its versatility lets formulators add it to water-based gels, emulsions or even hair sprays without affecting texture or scent.
Aminolevulinoyl Tripeptide-35’s Cosmetic Benefits/Uses
This multitasking peptide offers several perks when blended into personal care products:
- Bleaching – Helps reduce the look of dark spots and uneven tone by gently disturbing excess melanin on the skin surface, promoting a clearer brighter complexion without harsh irritation
- Hair Conditioning – Forms a light film on hair strands that smooths the cuticle, boosts softness and improves manageability, making it valuable in leave-in treatments and styling products
- Skin Protecting – Supports the skin barrier by binding water and reinforcing surface proteins, helping shield against environmental stressors and reducing visible signs of fatigue
Who Can Use Aminolevulinoyl Tripeptide-35
Aminolevulinoyl Tripeptide-35 is generally well tolerated by all skin types including dry, oily, combination and sensitive skin thanks to its lightweight water-compatible profile and absence of heavy oils or fragrances. Those with extremely reactive or compromised skin may still want to monitor their skin’s response because any new active could potentially trigger flushing or stinging in that group.
The peptide is synthesized from plant-derived building blocks in a lab so it is suitable for both vegans and vegetarians with no animal-origin ingredients used at any stage of production.
Current research has not flagged specific risks for pregnant or breastfeeding women when the ingredient is applied topically at cosmetic concentrations. Absorption through intact skin is minimal and systemic exposure is expected to be very low. That said this information is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before introducing new skincare products.
The molecule itself is less light-reactive than pure aminolevulinic acid but a mild increase in photosensitivity cannot be fully ruled out. Daytime users should pair it with broad-spectrum sunscreen and protective clothing, particularly during prolonged outdoor exposure.
Potential Side Effects/Adverse Reactions
Responses to topical Aminolevulinoyl Tripeptide-35 vary from person to person. The points below describe potential side effects that could occur even though most users will not experience them when the ingredient is formulated and used correctly.
- Temporary redness or warmth
- Mild itching or tingling at the application site
- Dry patches or flaking if layered with strong exfoliants
- Photosensitivity leading to quicker sunburn under intense UV exposure
- Allergic contact dermatitis in individuals sensitive to peptides or formulation preservatives
- Eye irritation if the product accidentally gets into the eyes
If any of these reactions develop discontinue use immediately and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Aminolevulinoyl Tripeptide-35 is a small, water-soluble peptide that does not leave an oily film on the skin or clog pores. It lacks heavy oils, waxes or fatty acids that typically trigger blackheads or breakouts, so it earns the lowest possible comedogenic score. This makes it suitable for people who are prone to acne or congestion.
Since the molecule is often used at low concentrations and quickly absorbs without residue, it is unlikely to interfere with other non-comedogenic ingredients in a well-balanced formula.
Summary
Aminolevulinoyl Tripeptide-35 brightens, conditions and protects. It helps fade dark spots by gently limiting excess surface pigment, smooths and softens hair by forming a light conditioning layer and boosts the skin barrier by binding moisture and supporting surface proteins.
The peptide is a newer, still-emerging player in beauty products so it is not as common as classics like niacinamide or hyaluronic acid, yet it is steadily gaining attention in targeted brightening serums and leave-in hair treatments.
Current research suggests it is safe for most users with a very low risk of irritation when used at standard cosmetic levels. As with any new skincare or hair care active it is smart to patch test a small area first to be sure your skin agrees with it.