What Is Aminopeptidase?
Aminopeptidase is a type of enzyme that belongs to the larger family of proteases, which are ingredients that cut long protein chains into smaller pieces. It can be obtained from plant sources such as soy or wheat germ, from certain friendly bacteria used in fermentation or produced through controlled laboratory fermentation using biotechnology. In the past these enzymes were mainly studied for food processing but formulators soon noticed that their gentle protein-cutting action could soften rough skin, so the ingredient made its way into personal care in the early 2000s.
Commercial production starts with a safe microbial strain that is fed a nutrient solution in a closed fermenter. The microbes make the enzyme, which is then filtered, purified and carefully dried or kept in a liquid base to protect its activity. Because it is water-soluble it is easy to add to finished products during the cool-down phase of manufacturing.
You are most likely to see aminopeptidase in rinse-off or leave-on exfoliating masks, anti-aging serums, lightweight moisturizers and post-shave balms where a smooth feel and quick skin renewal are desired.
Aminopeptidase’s Cosmetic Benefits/Uses
Formulators choose aminopeptidase mainly for one role
Skin conditioning: By trimming the very top layer of dull surface proteins the enzyme helps reveal fresher skin, leaving it softer and more even. Regular use can improve radiance, help other actives absorb better and support a more refined texture without the harsh feel that stronger acids or scrubs may cause.
Who Can Use Aminopeptidase
Aminopeptidase is generally suitable for most skin types, including oily, dry, normal and combination skin. Its gentle protein-trimming action means it is often tolerated even by mildly sensitive skin, though anyone with a compromised skin barrier or open wounds may wish to wait until the skin has recovered before introducing enzymatic products.
The enzyme is produced through fermentation and is not derived from animals, so it fits vegan and vegetarian lifestyles. Always check the full ingredient list in case the final formula contains non-vegan additives such as beeswax or collagen.
Current research shows no specific risks linked to topical aminopeptidase use during pregnancy or breastfeeding, but this is not medical advice. Pregnant or nursing individuals should review any skincare product with their physician to be extra cautious.
Aminopeptidase does not increase photosensitivity, so it can be used year-round without heightening the skin’s reaction to sunlight. Standard daytime sunscreen use is still recommended as part of any good skincare routine.
Potential Side Effects/Adverse Reactions
Responses to topical aminopeptidase can vary from person to person. The following list covers potential side effects that are possible yet uncommon when the ingredient has been properly formulated and applied.
- Mild tingling or warmth a temporary sensation that may occur as the enzyme begins working on surface proteins
- Redness or flushing usually short-lived and more likely if skin is already irritated
- Dryness or tightness if the product is overused or not followed with adequate moisturization
- Contact dermatitis rare allergic reaction that can present as itching, swelling or small bumps
- Interaction with other exfoliants using strong acids or scrubs in the same routine may amplify irritation
If any discomfort, persistent redness or rash develops stop use immediately and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Aminopeptidase is a water-soluble enzyme with no oily or waxy components so it does not sit in pores or create a film that could trap debris. As a result the risk of clogging pores is essentially nil. This makes it suitable for people prone to acne or frequent breakouts.
Keep in mind that the final formula matters. If an aminopeptidase product also contains heavy oils or butters those other ingredients, not the enzyme, could raise the overall comedogenic potential.
Summary
Aminopeptidase is used in skincare as a gentle protein-cutting enzyme that smooths rough surface cells, boosts radiance and helps other active ingredients sink in more easily. It offers a mild alternative to stronger acids or physical scrubs while remaining friendly to most skin types.
The ingredient is still a niche choice compared with popular exfoliants like glycolic acid but interest is growing as consumers look for kinder ways to refresh skin.
Safety data show a low risk of irritation or pore blockage when properly formulated. Even so it is wise to patch test any new product containing aminopeptidase before full use to make sure your skin agrees with it.