Amp-Isostearoyl Hydrolyzed Silk: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Amp-Isostearoyl Hydrolyzed Silk?

Amp-Isostearoyl Hydrolyzed Silk is a specialty ingredient that comes from silk fibers, the same material silkworms spin into cocoons. Chemists break down raw silk into smaller protein fragments, then react those fragments with isostearic acid, a fatty acid often sourced from coconut or soybean oil. The result is combined with aminomethyl propanol to create a salt form that blends easily with water and oils.

Interest in silk proteins for beauty dates back to the 1970s, when researchers noticed how silk left fabrics soft and lustrous. Smaller silk peptides were later found to bind well to hair and skin, so manufacturers began adding them to shampoos and lotions. By attaching a fatty acid like isostearic acid, the silk fragments became more compatible with modern formulations, leading to the launch of Amp-Isostearoyl Hydrolyzed Silk in the early 2000s.

The production process starts with cleaned silk fibers that are hydrolyzed under controlled heat and pH to create short peptides. These peptides react with isostearic acid chloride, forming a stable condensation product. Finally, aminomethyl propanol neutralizes the mixture to a skin-friendly pH, giving a versatile powder or liquid that disperses smoothly.

You will most often spot Amp-Isostearoyl Hydrolyzed Silk in leave-in conditioners, rinse-off shampoos, smoothing serums, nail strengtheners, facial moisturizers, anti-aging creams and wash-off masks where a silky after-feel is desired.

Amp-Isostearoyl Hydrolyzed Silk’s Cosmetic Benefits/Uses

This multi-purpose ingredient earns its keep by enhancing how products feel and perform on hair, skin and nails.

  • Hair conditioning: Forms a light film over strands that boosts softness, adds slip for easier detangling and imparts a subtle sheen without weighing hair down
  • Nail conditioning: Helps reinforce the nail surface, reducing brittleness and improving flexibility which can cut down on peeling or splitting
  • Skin conditioning: Provides a smooth, satin finish on the skin, supports moisture retention and leaves a soft touch that can make creams feel more luxurious

Who Can Use Amp-Isostearoyl Hydrolyzed Silk

Thanks to its lightweight silky film, this ingredient works for nearly every skin type including oily, combination, normal and dry. Sensitive skin usually tolerates it well because it has a neutral pH and lacks common irritants, although anyone with a known silk or silk protein allergy should avoid it as even trace amounts can trigger redness or itching.

Amp-Isostearoyl Hydrolyzed Silk is sourced from silkworm cocoons so it is not suitable for vegans or strict vegetarians. While some brands obtain silk under humane conditions, the raw material still originates from an animal source which places it outside plant based or cruelty free standards for those consumers.

The ingredient is considered low risk for women who are pregnant or breastfeeding when used in rinse off or leave on cosmetics. It does not penetrate deeply and is not known to interfere with hormones, yet this is not medical advice and anyone expecting or nursing should review new products with a healthcare professional to be certain

Unlike exfoliating acids or retinoids, Amp-Isostearoyl Hydrolyzed Silk does not cause photosensitivity. Normal sun protection practices remain sufficient. It is also compatible with most active ingredients and remains stable across a broad pH range, so it rarely clashes with other steps in a routine.

Potential Side Effects/Adverse Reactions

Reactions to topical Amp-Isostearoyl Hydrolyzed Silk vary by individual. The effects listed below are possible but uncommon when a product is formulated and used as directed

  • Localised redness or itching in those with silk protein allergies
  • Mild scalp or skin irritation from overuse in very high concentrations
  • Build up on fine hair that can leave strands limp if the product is not rinsed thoroughly

If you notice any discomfort stop using the product immediately and consult a qualified medical professional for guidance

Comedogenic Rating

Rating: 1/5. Amp-Isostearoyl Hydrolyzed Silk is mostly made of small silk peptides blended with a lightweight fatty acid, so it sits on the surface as a thin breathable film rather than clogging pores. It also rinses off easily and is used at modest levels in formulas. Because of this low tendency to block follicles it is generally suitable for acne-prone or breakout-prone skin. Only very oily skin types using a heavy leave-on product packed with this ingredient might notice any pore issues, which is rare.

Summary

Amp-Isostearoyl Hydrolyzed Silk is a versatile conditioner for hair, skin and nails. The silk peptides grip to the surface while the isostearic fatty chain adds smoothness, together creating a soft protective layer that improves slip, boosts moisture feel and reinforces delicate keratin structures. It is not the most talked-about ingredient on social media but formulators value it for giving products a silky luxury finish without heaviness.

Overall it shows an excellent safety profile: low irritation risk, minimal comedogenicity and broad compatibility with other actives. As with any new cosmetic it is wise to patch test first to rule out personal sensitivities before full use.

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