Amyloglucosidase: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Amyloglucosidase?

Amyloglucosidase, often called glucoamylase, is an enzyme that breaks large starch molecules into tiny sugar units. It is usually obtained through the controlled fermentation of friendly microorganisms such as Aspergillus niger or certain bacteria. After the microbes make the enzyme, the mixture is filtered, purified and sometimes dried to form a stable powder or liquid that can be added to cosmetic formulas.

The enzyme first earned its place in the food and brewing industries, where it helps turn starch into fermentable sugars. Formulators later noticed that the same gentle starch-breaking ability could improve the feel and performance of skin care products. Today amyloglucosidase appears in face masks, exfoliating cleansers, anti aging serums, scalp scrubs and even some lightweight moisturizers where a smooth, refined texture is desired.

Amyloglucosidase’s Cosmetic Benefits/Uses

In topical products amyloglucosidase is mainly valued for its skin conditioning action. By quietly working on residual starches or other carbohydrate traces on the skin surface it leaves the skin feeling softer and smoother. This can make a formula feel more elegant, help other ingredients spread evenly and give the complexion a refreshed look.

Who Can Use Amyloglucosidase

Amyloglucosidase is generally gentle enough for all skin types including dry, oily, combination and mature skin. Its mild nature means it rarely strips moisture or upsets the skin barrier, so even sensitive users often tolerate it well. People with a known enzyme allergy or very reactive skin should still proceed cautiously, as any protein can occasionally trigger irritation.

The enzyme is produced by fermenting microorganisms rather than being taken from animals, so it is suitable for vegans and vegetarians provided the finished formula is free of other animal derived ingredients.

No data suggest the enzyme poses a problem for women who are pregnant or breastfeeding when used topically. That said this is not medical advice and anyone who is pregnant or nursing should show their healthcare provider the full ingredient list of any product they plan to use just to be safe.

Amyloglucosidase does not make skin more sensitive to sunlight and it has no known issues with daily sun exposure.

Potential Side Effects/Adverse Reactions

Side effects from topical amyloglucosidase differ from person to person. The points below outline potential reactions, though most users will not experience them when the ingredient is included at appropriate levels in a well formulated product.

  • Mild stinging or tingling right after application
  • Temporary redness or warmth in very sensitive skin
  • Itchiness or small patches of irritation if an allergy to the enzyme exists
  • Eye irritation if the product accidentally gets into the eyes
  • Exacerbated sensitivity on skin with an impaired barrier such as eczema or open cuts

If any of these reactions occur stop using the product and seek advice from a qualified healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 out of 5. Amyloglucosidase is a water-soluble enzyme that leaves no oily or waxy residue on the skin, so it does not clog pores or trap dead cells in the follicle. Because it is used in very small amounts and rinses away easily, there is minimal chance of it contributing to blackheads or breakouts.

Suitable for acne-prone or breakout-prone skin.

The only situation that might change this rating is if the enzyme is blended with heavier emollients that already have comedogenic potential, in which case the finished product’s rating would depend on those other ingredients rather than the enzyme itself.

Summary

Amyloglucosidase is a gentle, vegan-friendly enzyme that conditions the skin by breaking down microscopic starch residues so formulas feel smoother, spread better and leave the complexion softer. Its water-soluble nature means it rinses clean and does not weigh the skin down.

The ingredient is still something of a niche player, showing up mostly in higher-end masks, exfoliating cleansers and a few lightweight serums rather than in every drugstore lotion on the shelf.

Overall safety is high with very low irritation or allergy rates when used at typical cosmetic levels, yet it is always smart to patch test any new product to make sure your individual skin agrees with the formula.

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