Anacardoyl Tripeptide-35: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Anacardoyl Tripeptide-35?

Anacardoyl Tripeptide-35 is a hybrid ingredient created when anacardic acid, a natural compound found in cashew nutshell liquid, reacts with a small chain of three amino acids known as Tripeptide-35. The result is a molecule that blends the plant based strength of anacardic acid with the skin friendly signaling power of a peptide.

The use of cashew nutshell extracts in folk remedies inspired researchers to isolate anacardic acid for its antioxidant ability. Peptide technology later offered a way to boost and refine those benefits, leading to the development of Anacardoyl Tripeptide-35 in modern cosmetic labs. The ingredient is produced through a controlled condensation process that bonds the acid to the peptide, followed by purification steps to ensure stability and skin safety.

Because it is both protective and brightening, Anacardoyl Tripeptide-35 shows up in a wide range of topical formulas. You can find it in daily moisturizers, anti aging serums, brightening spot treatments, sheet masks, eye creams and even in some after sun gels.

Anacardoyl Tripeptide-35’s Cosmetic Benefits/Uses

This multitasking ingredient supports skin health on several fronts, making it popular with product developers looking for visible results.

  • Antioxidant: Helps neutralize free radicals from pollution and UV exposure, which can slow the look of premature aging and keep skin appearing fresh
  • Bleaching: Contributes to a more even tone by gently reducing the appearance of dark spots and surface discoloration for a brighter complexion
  • Skin Protecting: Forms a lightweight defensive layer that supports the skin barrier, helping it stay hydrated and less reactive to daily stressors

Who Can Use Anacardoyl Tripeptide-35

Anacardoyl Tripeptide-35 is gentle enough for most skin types including dry, oily, combination and mature skin. Its lightweight texture will not add heaviness to oily complexions while its barrier supporting action can comfort dry or sensitive skin. Those with a known cashew or tree nut allergy should proceed with caution because the ingredient originates from cashew nutshell liquid, and although highly purified trace allergens could remain.

The molecule is synthesized without animal inputs so it is considered suitable for both vegetarians and vegans. As always, confirm the finished product’s wider formula and manufacturing standards if plant based status is important to you.

No data suggest that topical Anacardoyl Tripeptide-35 poses a specific risk to women who are pregnant or breastfeeding when used in normal cosmetic concentrations. This is not medical advice and anyone who is expecting or nursing should run new skincare products past a qualified healthcare provider to be on the safe side.

The ingredient does not increase photosensitivity. In fact its antioxidant action helps defend against sun related oxidative stress, though daily sunscreen remains essential for overall protection.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Anacardoyl Tripeptide-35 can vary from person to person. The points below list potential issues that could arise although most users will not experience them when the ingredient is formulated and used correctly.

  • Contact irritation such as redness stinging or a mild burning sensation
  • Allergic response in individuals sensitive to cashew or other tree nuts
  • Dryness or flakiness when layered with strong exfoliating acids or retinoids
  • Temporary tingling in very reactive or compromised skin

If you experience any adverse effect discontinue use and seek advice from a dermatologist or healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Anacardoyl Tripeptide-35 is primarily a water-soluble peptide complex, so it does not behave like heavier plant oils that can clog pores. The anacardic portion is tightly bound to the peptide and is present at very low use levels, which further minimizes any pore-blocking risk. For these reasons the ingredient earns a low score of 1, meaning it is generally considered non-comedogenic.

Most people prone to acne or breakouts can use products containing Anacardoyl Tripeptide-35 without seeing extra congestion, though the overall formula it sits in still matters.

If the ingredient is delivered in a cream rich in occlusive waxes the finished product’s comedogenicity may be higher, so always check the full ingredient list.

Summary

Anacardoyl Tripeptide-35 acts as an antioxidant, a gentle tone-brightener and a skin barrier supporter. The anacardic acid part mops up free radicals while the peptide segment signals skin to stay resilient and even-toned, giving a twofold approach to protection and brightness.

It is not yet a mainstream buzzword like vitamin C or retinol, but formulators appreciate its multitasking profile and compatibility with most actives so its presence is slowly growing in premium serums and moisturizers.

Current research and user reports show it to be well tolerated for everyday use with only rare irritation or allergy concerns. As with any new cosmetic ingredient it is smart to patch test a small area first to ensure personal comfort and safety.

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