Avocado Oil Polyglyceryl-6 Esters: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Avocado Oil Polyglyceryl-6 Esters?

Avocado Oil Polyglyceryl-6 Esters is a plant-derived ingredient created by joining nourishing avocado oil with polyglycerin-6, a chain of glycerin units that loves water. Through a controlled process called transesterification, the fatty parts of avocado oil bond with the water-friendly polyglycerin-6, producing a hybrid molecule that blends well with both oil and water. This union keeps many of the vitamins and fatty acids that make avocado oil famous while adding the easy mixability offered by polyglycerin-6.

Avocado oil has been prized in skin care since ancient Central American cultures applied the fruit’s pulp to soften skin. Modern chemists took that time-tested oil and, in the last couple of decades, paired it with polyglycerin-6 to meet the rising demand for plant-based emulsifiers that are gentle on skin and the environment. The resulting esters entered commercial cosmetic formulas as brands sought greener options to replace petroleum or animal-derived emulsifiers.

To make Avocado Oil Polyglyceryl-6 Esters, manufacturers heat and blend refined avocado oil with polyglycerin-6 in the presence of a catalyst. The reaction swaps parts of the molecules, yielding a stable ester that can dissolve in both oil and water phases. After purification and quality checks, the ingredient arrives as a light, low-odor liquid that is easy to add during the cool-down step of product manufacturing.

You will most often find Avocado Oil Polyglyceryl-6 Esters in moisturizers, facial oils, masks, gentle cleansers, baby care, sun care and anti-aging creams where it helps keep formulas smooth and skin-friendly.

Avocado Oil Polyglyceryl-6 Esters’s Cosmetic Benefits/Uses

This multitasking ingredient offers several perks that improve how a product feels, looks and performs

  • Skin Conditioning: Supplies skin with essential fatty acids and natural vitamin E from avocado oil, leaving it soft, supple and visibly healthier
  • Emollient: Fills in tiny cracks on the skin surface, smoothing rough patches and improving overall texture without a greasy afterfeel
  • Cleansing: Lifts away dirt and makeup while respecting the skin barrier thanks to its balanced oil-and-water loving structure, making it ideal for gentle cleansers and micellar products
  • Emulsifying: Helps oil and water mix uniformly so creams, lotions and serums stay stable, silky and free from separation during shelf life

Who Can Use Avocado Oil Polyglyceryl-6 Esters

This ingredient is gentle and lightweight enough for nearly all skin types, including dry, normal, combination and sensitive skin. Its balanced oil to water affinity lets it moisturize without leaving heavy residue, so even those with oily or blemish-prone skin usually tolerate it well. The one group that may need caution is anyone with a known avocado allergy, since trace proteins from the original oil could remain and trigger irritation.

Because both the avocado source and the polyglycerin backbone are plant based, Avocado Oil Polyglyceryl-6 Esters fits vegan and vegetarian preferences and involves no animal-derived raw materials or testing at the ingredient level.

Current safety data show no specific risks for women who are pregnant or breastfeeding when the ingredient is used topically in cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should ask a healthcare professional before adding new products to their routine, just to be safe.

Avocado Oil Polyglyceryl-6 Esters does not increase the skin’s sensitivity to sunlight and can be used day or night without raising the chance of sunburn. It also plays well with common actives like retinol, niacinamide and vitamin C, making it a flexible choice in layered routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Avocado Oil Polyglyceryl-6 Esters vary from person to person. The points below list potential side effects, but most users will not experience them when the ingredient is correctly formulated and used as intended.

  • Allergic contact dermatitis – rare redness, itching or swelling in individuals sensitive to avocado components
  • Mild stinging or warmth – transient sensation on very reactive or freshly exfoliated skin
  • Clogged pores – occasional congestion in people extremely prone to comedones if heavy formulas are applied too frequently
  • Exacerbation of existing eczema – possible flare if skin is severely compromised and reacts to any new lipid source

If irritation, rash or any unexpected reaction occurs stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Transforming avocado oil into polyglyceryl-6 esters strips most of the heavier triglycerides that can block pores while adding water-loving glycerin units. The resulting molecule spreads thinly and rinses clean, making it far less likely to sit in follicles and cause congestion than raw avocado oil itself. Because a small fraction of fatty components remains, the rating is not a perfect zero but it is still considered very low on the scale.

Suitable for acne-prone or breakout-prone skin in most formulations.

Keep in mind that the overall comedogenicity of a finished product depends on the full ingredient list and how much Avocado Oil Polyglyceryl-6 Esters is used.

Summary

Avocado Oil Polyglyceryl-6 Esters conditions skin, acts as an emollient, lifts away impurities and keeps oil and water phases blended. It does this by pairing nurturing avocado-derived fatty acids with a multi-unit glycerin backbone that loves water, giving the molecule a foot in both worlds so it can soften skin, trap dirt then rinse away and stabilize emulsions.

The ingredient is gaining popularity among brands seeking plant-based alternatives to synthetic emulsifiers yet it is still something of a hidden gem compared with household names like shea butter or jojoba oil.

Current research and decades of use show it is generally safe for all skin types with very low irritation or comedogenic risk. As with any new cosmetic ingredient it is wise to perform a small patch test when trying a product that contains it just to be cautious.

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