Barley Sh-Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Barley Sh-Polypeptide-1?

Barley Sh-Polypeptide-1 is a lab made version of a short chain protein that mimics a naturally occurring growth factor, produced in transgenic barley. Scientists insert a piece of genetic code into barley plants so the grain can manufacture the desired polypeptide in its seeds. After harvesting, the seeds are milled, the protein is isolated through filtration and purification, then it is dried into a stable powder ready for cosmetic use.

The idea of using plants as mini factories for skin care actives began gaining ground in the early 2000s, offering a vegan and scalable alternative to animal or bacteria derived proteins. Barley quickly became a favorite because it grows in many climates and its seeds protect delicate proteins from breaking down during cultivation.

Barley Sh-Polypeptide-1 shows up in a wide range of leave-on and rinse-off products. You will find it in lightweight serums, anti aging creams, sheet masks, soothing gels, hair strengthening sprays, conditioners and scalp tonics. Its small size lets it blend smoothly into water based formulas without adding weight or greasiness.

Barley Sh-Polypeptide-1’s Cosmetic Benefits/Uses

This ingredient serves more than one purpose, making it a flexible addition to skin and hair care formulas.

  • Hair conditioning: the polypeptide forms a thin film over each strand, helping hair hold moisture, feel smoother and look shinier. It can also reduce static so styling becomes easier.
  • Skin conditioning: on the skin it supports a soft, hydrated feel by attracting water and reinforcing the surface barrier. Regular use can leave skin looking firmer and more supple which is why it is popular in anti aging lines.

Who Can Use Barley Sh-Polypeptide-1

Thanks to its lightweight water soluble nature Barley Sh-Polypeptide-1 generally suits dry, normal, combination and oily skin alike. It adds moisture without clogging pores or leaving a heavy residue so acne-prone users usually tolerate it well. Sensitive skin tends to accept the ingredient too although anyone with a diagnosed barley or gluten allergy should approach with caution since trace proteins could remain after purification.

The polypeptide is produced entirely in plants so it aligns with vegan and vegetarian lifestyles. No animal by-products or animal testing are required to obtain or refine the ingredient, making it a popular choice for cruelty-free formulas.

Current safety data do not flag issues for pregnant or breastfeeding women when the ingredient is applied topically at typical cosmetic levels. That said this information is not medical advice and anyone expecting or nursing should review all personal care products with a qualified healthcare professional to be certain they fit individual needs.

Barley Sh-Polypeptide-1 does not cause photosensitivity and can be used morning or night without increasing vulnerability to sunburn, though daily sunscreen remains important for overall skin health.

Potential Side Effects/Adverse Reactions

Side effects from topical Barley Sh-Polypeptide-1 differ from person to person. The points below reflect potential reactions only; most users experience none of them when the ingredient is formulated and used correctly.

  • Mild redness or stinging especially on very reactive skin when first applied
  • Itching or hives in individuals allergic to barley or related grains
  • Contact dermatitis if the skin becomes sensitized to the protein after repeated exposure
  • Scalp buildup leading to dullness or limp hair when high concentrations are left on without regular cleansing

If irritation or any negative response occurs stop using the product and seek guidance from a medical professional.

Comedogenic Rating

Rating: 0–1 (non to very low comedogenic potential)

Barley Sh-Polypeptide-1 is a small, water-soluble protein that rinses cleanly and does not leave an oily film on skin or hair. Because it lacks heavy lipids or waxes that can block pores, formulators classify it at the bottom of the comedogenic scale. This makes the ingredient generally suitable for people who are prone to acne or breakouts. Very high concentrations in leave-on products could, in theory, lead to residue buildup, but typical levels used in cosmetics are too low to cause clogging.

Summary

Barley Sh-Polypeptide-1 mainly conditions skin and hair by forming a light moisturizing film that helps strands stay smooth and skin feel soft and firm. It attracts water, supports the surface barrier and can add a touch of strength and shine to hair.

Although not as famous as hyaluronic acid or collagen, this barley-derived peptide is gaining traction in vegan and cruelty-free formulations because it offers similar benefits without animal sourcing. You will spot it most often in mid to premium serums, masks and leave-in conditioners.

Current research and in-use data show a strong safety profile with little risk of irritation unless someone has a barley allergy. As with any new cosmetic, do a simple patch test when you first try a product containing Barley Sh-Polypeptide-1 to be sure it suits your individual skin.

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