Barley Sh-Polypeptide-3: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Barley Sh-Polypeptide-3?

Barley Sh-Polypeptide-3 is a bioengineered chain of amino acids produced in specially cultivated barley plants. Scientists insert a gene that codes for a skin friendly peptide into the barley, allowing the grain to grow this peptide naturally. Once harvested the plants are processed to isolate and purify the polypeptide, which is then blended into cosmetic bases. The result is a plant sourced version of a peptide that would otherwise be made synthetically or taken from animal tissues.

The idea of using transgenic plants for skincare started gaining traction in the early 2000s when researchers looked for greener ways to make complex proteins. Barley proved attractive because it grows quickly, needs modest resources and can be farmed in controlled conditions. Over time manufacturers refined extraction methods so the final ingredient meets cosmetic grade standards.

Today Barley Sh-Polypeptide-3 shows up in a range of topical products. You might find it in lightweight anti aging serums, hydrating moisturizers, sheet masks, eye creams and overnight treatments designed to support smoothness and elasticity. Because it is water soluble it blends well into gel and lotion textures without leaving a heavy feel.

Barley Sh-Polypeptide-3’s Cosmetic Benefits/Uses

In skincare formulas Barley Sh-Polypeptide-3 serves one main role: skin conditioning. By helping the surface of the skin stay hydrated and soft, it can improve overall texture and give a healthier look. Formulators choose it to boost moisture retention, support a supple feel and enhance the comfort of both daily hydrators and targeted treatments.

Who Can Use Barley Sh-Polypeptide-3

This peptide is gentle enough for most skin types including dry, normal, combination and oily. People with sensitive or easily reactive skin usually tolerate it well because it has a low risk of irritation and is added at modest levels. Those with grain allergies or celiac disease should check with a doctor first since the raw material comes from barley and could carry trace proteins that bother some individuals.

Because the peptide is produced in plants rather than animals it is suitable for vegans and vegetarians. The manufacturing process does not use animal derivatives so the finished ingredient aligns with plant based lifestyles.

No specific warnings exist for women who are pregnant or breastfeeding. Current data shows the peptide sits on the surface of the skin and is unlikely to enter the bloodstream. This is not medical advice and anyone who is pregnant or nursing should run all skincare choices by a health professional just to be safe.

Barley Sh-Polypeptide-3 does not increase photosensitivity so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended as part of a healthy routine.

Potential Side Effects/Adverse Reactions

Reactions to any cosmetic ingredient can vary from person to person. The points below list potential side effects that could occur even though most users will not experience them when the product is made and used as directed.

  • Allergic contact dermatitis – rare redness itching or rash in people who are sensitive to barley proteins or the peptide itself
  • Cross reactivity for grain sensitive users – discomfort or flare ups in those with known barley or gluten related conditions
  • Mild stinging or warmth – short lived tingling that sometimes appears when first applied to compromised or freshly exfoliated skin
  • Sensitization over time – very uncommon delayed irritation if the skin develops a sensitivity after long term daily use

If any persistent redness swelling or discomfort appears stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 0 / 5 – Barley Sh-Polypeptide-3 is water soluble and used in very small concentrations so it does not leave an occlusive film that could trap oil or debris inside pores. It contains no fatty acids or heavy waxes that traditionally clog skin. This makes it a safe pick for people who are prone to acne or breakouts.

Because the peptide is usually paired with lightweight gel or lotion bases its presence rarely changes the overall pore-clogging potential of a formula. Any comedogenic risk will come from richer oils or butters in the product rather than from the peptide itself.

Summary

Barley Sh-Polypeptide-3 is a plant sourced peptide that conditions skin by boosting surface hydration and softness. It does this by binding water and supporting the natural moisture barrier so skin feels smoother and more supple.

While not yet a mainstream headline ingredient it is quietly gaining traction in niche serums masks and moisturizers thanks to its gentle profile and vegan origin. Most users tolerate it well with minimal reports of irritation or clogged pores.

Current data suggests the ingredient is low risk for the vast majority of skin types including sensitive and acne prone. As with any new skincare product it is wise to perform a quick patch test to make sure your skin agrees before applying it to the entire face.

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