Biphenyl Azepanyl Methanone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Biphenyl Azepanyl Methanone?

Biphenyl Azepanyl Methanone is a lab crafted molecule whose full chemical name is methanone, [1,1′-biphenyl]-3-yl(hexahydro-1H-azepin-1-yl). At its core it joins a biphenyl ring structure to a seven-membered nitrogen-containing ring called an azepane, with a small carbonyl bridge linking the two. This marriage of rings gives the ingredient a balanced mix of rigidity and flexibility, traits formulators like when they want a lightweight feel on skin.

The compound does not come from a plant or animal; it is synthesized in controlled conditions from petrochemical or bio-based aromatic precursors. Chemists first build the biphenyl backbone through a coupling reaction, then introduce the azepane ring via selective hydrogenation of a cyclic imine, and finally connect the two fragments through a Friedel–Crafts acylation that installs the methanone group. The resulting material is purified, checked for residual solvents and standardized to cosmetic grade powder or liquid concentrate.

Interest in Biphenyl Azepanyl Methanone rose during the early 2010s when researchers looked for silicone alternatives that could smooth skin without leaving an oily film. Its low surface tension and film-forming ability made it a compelling choice. Small scale trials showed it boosted softness and reduced transepidermal water loss, so brands started adding it to premium moisturizers and overnight masks.

Today you will most often spot it on ingredient lists for daily moisturizers, anti-aging serums, hydrating sheet masks and leave-on treatments aimed at strengthening the skin barrier. Because it is compatible with both water-based and oil-based phases, formulators use it in creams, gels and even some lightweight facial oils.

Biphenyl Azepanyl Methanone’s Cosmetic Benefits/Uses

This ingredient offers two main functions that improve the performance and sensorial feel of a product

  • Skin Conditioning: Forms a breathable microfilm that smooths rough patches, boosts softness and imparts a silky after-touch. Over time regular use can leave the complexion looking more even and supple
  • Skin Protecting: The microfilm also acts as a barrier that limits water loss and shields skin from everyday irritants like pollution particles or harsh detergents helping maintain long term hydration and comfort

Who Can Use Biphenyl Azepanyl Methanone

Most skin types can tolerate Biphenyl Azepanyl Methanone. Its light feel and non-greasy film make it suitable for normal, dry, combination or sensitive skin. Oily or breakout-prone users generally do well because the molecule does not add heavy oils that block pores, though exceptionally acne-prone individuals may still want to keep an eye on how their skin responds. People with a history of reactions to synthetic aromatic compounds should approach with caution since the ingredient is lab derived.

The compound is made without animal raw materials and is not tested on animals in regions that follow modern cosmetics regulations, so it is considered friendly for vegans and vegetarians.

No data point to hormonal or developmental concerns, so pregnant or nursing women can usually use products that contain it. This is not medical advice and anyone who is pregnant or breastfeeding should show the full ingredient list to their healthcare provider before adding a new product, just to be safe.

Biphenyl Azepanyl Methanone is not known to cause photosensitivity. Standard daily sunscreen use is still advised for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical Biphenyl Azepanyl Methanone vary by individual. The effects below are possible but unlikely when the ingredient is properly formulated and used as directed.

  • Mild redness or warmth at the application site
  • Temporary stinging or itching on very sensitive skin
  • Rare allergic contact dermatitis presenting as rash or swelling
  • Eye irritation if the product migrates into the eyes
  • Occasional clogged pores in individuals already prone to congestion

If you notice any of these reactions stop using the product and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. Biphenyl Azepanyl Methanone creates a thin breathable film rather than a heavy occlusive layer so it is unlikely to trap oil or debris in pores. It is a mid-weight synthetic molecule that lacks the long fatty chains often linked to clogged pores. In most finished formulas it is used at low concentrations which further lowers the risk of congestion. Overall it is generally suitable for people prone to acne or breakouts. Keep in mind the final product’s whole ingredient blend and personal skin habits also influence whether pores become blocked.

Summary

Biphenyl Azepanyl Methanone acts mainly as a skin conditioner and skin protectant. It forms a lightweight microfilm that smooths texture boosts softness and slows moisture from escaping which keeps the skin barrier comfortable and resilient. Its balanced structure lets it spread easily without greasiness so products feel silky rather than slick.

The ingredient is gaining steady popularity in modern moisturizers serums and overnight masks as brands look for silicone alternatives that still deliver a velvety finish. While not as common as classic emollients it is turning up more often in mid to premium formulas aimed at barrier care and hydration.

Safety data indicate a low risk of irritation or sensitization when used as directed. As with any new skincare product patch testing on a small area first is a smart way to confirm personal tolerance before full-face use.

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