Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 23, 2025
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All information on this page is verified using The Personal Care Products Council's (PCPC) INCI database. Our ingredient analyses are based exclusively on PCPC's technical data to ensure accuracy and reliability.

What Is Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate?

Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate is a lab-crafted ingredient made by linking sebacic acid, a plant-derived fatty acid often sourced from castor oil, with two molecules from a family of gentle nitrogen-based rings called piperidines. The result is a silky, oil-like compound that dissolves well in both water-loving and oil-loving phases of a formula. It first gained attention in the plastics industry where similar “hindered amine” structures protect materials from sunlight. When chemists noticed its ability to stabilize and moisturize surfaces, they adapted it for skin care. Today manufacturers create it through a controlled esterification process that purifies the final material to cosmetic grade. You will usually spot it in lightweight moisturizers, anti-aging serums, overnight masks, color-cosmetics that promise skin care benefits, sunscreen boosters and soothing after-sun lotions.

Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate’s Cosmetic Benefits/Uses

This multitasker offers several skin-friendly perks that help modern formulas feel better and perform longer.

  • Humectant – attracts water from the surrounding air and pulls it toward the skin surface which keeps skin looking plumper and less flaky
  • Skin Conditioning – leaves a soft, smooth feel that makes skin look healthier and more even
  • Emollient – fills in tiny gaps between skin cells so rough patches feel silky and flexible
  • Skin Protecting – forms a light, invisible film that shields skin from drying wind and pollution helping other active ingredients last longer on the skin

Who Can Use Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate

This ingredient plays nicely with most skin types. Its lightweight emollient feel makes it a match for normal, combination and dry skin while the non-greasy finish keeps oily skin from feeling overloaded. Sensitive skin usually tolerates it because it is free of fragrance and known irritants. Those struggling with very reactive or allergy-prone skin should still check the full ingredient list of a product to see what else is inside.

Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate is synthesized in the lab from plant-derived sebacic acid, so it contains no animal material. That makes it suitable for vegans and vegetarians as long as the finished product is also free of animal-based additives elsewhere in the formula.

Current safety data show no specific risks for pregnant or breastfeeding women when the ingredient is used topically in cosmetic amounts. Still, this is not medical advice and anyone who is expecting or nursing should have a quick word with a healthcare professional before adding new skincare to their routine.

The molecule does not make skin more sensitive to sunlight, so it is not considered photosensitizing. It can even sit well in day creams and sunscreens because of its stabilizing nature. There are no known ingredient conflicts, and it layers without trouble under makeup or over actives like vitamin C and niacinamide.

Potential Side Effects/Adverse Reactions

Responses to any skincare ingredient can differ from person to person. The points below cover possible but uncommon reactions linked to topical Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate when it is included at standard cosmetic levels. Properly formulated products are unlikely to trigger these issues for most users.

  • Mild redness or stinging on very sensitive skin
  • Temporary itching if applied to broken or freshly exfoliated skin
  • Rare allergic contact dermatitis in individuals already allergic to piperidine derivatives
  • Occlusive feel for those who dislike any film-forming ingredients

If any discomfort, persistent redness or swelling develops stop using the product and consult a qualified medical professional.

Comedogenic Rating

Rating: 1 / 5

Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate is an airy ester that spreads well and absorbs without leaving a waxy or heavy residue. It does not contain long chain fatty acids or butters that are known to clog pores. In consumer use tests and published supplier data it shows no tendency to provoke blackheads or whiteheads, so it earns a very low score. The small risk comes from its light occlusive film which, in rare cases, could trap debris if someone already has congested pores.

Overall it is considered suitable for skin that is prone to acne or breakouts.

Worth noting: as with most ingredients, the final product texture and the presence of other comedogenic materials have a bigger influence on pore clogging than this molecule on its own.

Summary

Bis-(Tetramethyl Hydroxypiperidinyl) Sebacate pulls water to the skin as a humectant, softens rough patches as an emollient, conditions the surface for a smooth feel and forms a protective veil that guards against moisture loss and pollution. It accomplishes these jobs thanks to its balanced oil-and-water friendly structure that locks onto moisture while leaving a breathable finish.

The ingredient is not yet a household name, but formulators value its multitasking nature so it is starting to show up in modern moisturizers, sunscreens and hybrid makeup.

Current research and global regulatory reviews label it safe for topical use at the levels found in cosmetics. Still, skin is personal so it is wise to patch test any new product containing this ester before applying it to the entire face.

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