C14-20 Isoalkylamidopropylethyldimonium Ethosulfate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is C14-20 Isoalkylamidopropylethyldimonium Ethosulfate?

C14-20 Isoalkylamidopropylethyldimonium Ethosulfate is a quaternary ammonium compound made by reacting fatty acids derived from mid to long chain plant oils with a small nitrogen containing molecule, then neutralizing the result with ethyl sulfate. The fatty acids selected usually fall between 14 and 20 carbon atoms, giving the ingredient its name. First developed in the late twentieth century as chemists searched for gentler yet effective hair conditioning agents, it quickly found favor thanks to its ability to reduce static without leaving heavy buildup.

The manufacturing process starts with splitting natural fats such as coconut or tallow to obtain isolated fatty acids. These acids are converted to fatty acid chlorides, reacted with a propyl dimethyl ethylamine, then quaternized with ethyl sulfate to form a stable, water dispersible salt. The finished ingredient is a clear to pale yellow liquid that blends easily into water based formulations.

You will most often spot C14-20 Isoalkylamidopropylethyldimonium Ethosulfate in rinse off and leave in hair conditioners, smoothing masks, detangling sprays, anti frizz creams and 2 in 1 shampoos. It also appears in beard balms and some skin lotions where light conditioning is desired.

C14-20 Isoalkylamidopropylethyldimonium Ethosulfate’s Cosmetic Benefits/Uses

This ingredient is added to beauty products for two main reasons

  • Antistatic – Helps neutralize electrical charges that cause flyaways so hair lies flatter and is easier to style
  • Hair Conditioning – Deposits a thin, lubricating layer on the hair shaft making strands feel softer, look shinier and comb more smoothly

Who Can Use C14-20 Isoalkylamidopropylethyldimonium Ethosulfate

This conditioning agent is gentle enough for most scalp and hair types including oily, dry, combination and sensitive. Because it is water dispersible and rinses cleanly it rarely weighs down fine hair or aggravates oily roots. People with extremely sensitive or broken skin should still monitor for any stinging or redness as with any new cosmetic ingredient.

The fatty acids used to make C14-20 Isoalkylamidopropylethyldimonium Ethosulfate can come from coconut, palm or animal fats. Many personal care brands specify vegetable sourced material, yet this is not guaranteed. Strict vegans and vegetarians should look for a clear plant origin statement or certification from the manufacturer before using a product that contains it.

No data indicate that the ingredient poses a special risk to pregnant or breastfeeding women when used topically at typical cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new hair or skin products to their routine.

The compound is not known to increase photosensitivity and has no reported interactions with sun exposure. It is also compatible with most other common hair care ingredients including silicones, proteins and botanical extracts.

Potential Side Effects/Adverse Reactions

Reactions to topical C14-20 Isoalkylamidopropylethyldimonium Ethosulfate vary from person to person. The following list covers possible but uncommon side effects assuming the formula has been produced correctly and used as directed. Most people will not experience any of these issues.

  • Mild scalp or skin irritation itching or redness can occur in those highly sensitive to cationic surfactants
  • Allergic contact dermatitis rare allergic reactions have been reported with quaternary ammonium compounds leading to rash or swelling
  • Eye irritation accidental contact may cause stinging or watering until thoroughly rinsed out
  • Buildup with overuse heavy application in leave in products could leave hair feeling greasy or limp until clarified

If any negative reaction develops stop using the product immediately and seek medical advice if symptoms persist or worsen.

Comedogenic Rating

Rating: 1/5

C14-20 Isoalkylamidopropylethyldimonium Ethosulfate is a water dispersible quaternary ammonium salt that bonds to hair rather than settling into skin pores. Its charged nature keeps it on the surface and allows it to rinse away easily, so the chance of it blocking follicles is very low. Most people who struggle with acne can use products containing this ingredient without seeing an uptick in breakouts.

Because it is found mainly in rinse off conditioners any residue left on facial skin is minimal. Only rich leave in creams that brush against the hairline might create a slight risk of congestion.

Summary

C14-20 Isoalkylamidopropylethyldimonium Ethosulfate delivers antistatic and conditioning benefits by clinging to the negatively charged hair shaft then smoothing cuticles with its fatty tail so strands feel softer, look shinier and comb more easily.

It is not a household name yet but formulators appreciate its light after feel and reliable performance which has earned it a growing spot beside more established conditioning quats.

Available safety data point to a low likelihood of irritation toxicity or pore clogging when used within standard cosmetic limits. Still every scalp and skin type is different so patch testing a new product that features this ingredient is the safest way to rule out personal sensitivity.

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