Caffeine Carboxyloyl Sh-Decapeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Caffeine Carboxyloyl Sh-Decapeptide-1?

Caffeine Carboxyloyl Sh-Decapeptide-1 is a lab-crafted ingredient that joins two familiar skin care components: caffeine, the energizing compound naturally found in coffee beans and tea leaves, and Sh-Decapeptide-1, a lab-synthesized chain of ten amino acids designed to mimic signals found in healthy skin. Chemists first convert caffeine into caffeine carboxylic acid, giving it a handy “hook” that lets it bond to the peptide. Through controlled mixing and purification steps in a sterile setting, the two pieces are linked to form a single, stable molecule with both caffeine’s invigorating character and the peptide’s skin-friendly profile.

Interest in peptide technology took off in the early 2000s when brands looked for gentle ways to support collagen and firmness. Adding caffeine, already popular for eye-area products, was the next step. The combined ingredient started appearing in premium skin care formulas in the past decade as suppliers perfected the coupling process and proved the molecule’s stability in creams and gels.

You will most often spot Caffeine Carboxyloyl Sh-Decapeptide-1 in lightweight eye serums, de-puffing roll-ons, firming masks, anti-aging concentrates, brightening moisturizers and targeted ampoules meant to refresh tired or dull skin.

Caffeine Carboxyloyl Sh-Decapeptide-1’s Cosmetic Benefits/Uses

This ingredient is valued for its primary role as a skin conditioning agent, meaning it helps keep skin looking and feeling its best. By combining caffeine’s natural ability to wake up the skin surface with a peptide that can support a smoother texture, it can leave the complexion feeling refreshed, comfortably hydrated and visibly more toned after use.

Who Can Use Caffeine Carboxyloyl Sh-Decapeptide-1

This ingredient is generally friendly to most skin types. Its lightweight nature makes it a good pick for normal, oily and combination skin that prefers quick-absorbing formulas, while the peptide component offers a touch of comfort for drier complexions. Sensitive skin usually tolerates it well since the molecule was built to be gentle, though anyone with a known caffeine allergy should steer clear. Because it is synthetically produced without animal by-products it is suitable for vegans and vegetarians.

No specific warnings exist for people who are pregnant or breastfeeding, yet research on this exact molecule is still limited. This content is not medical advice, and expectant or nursing mothers should ask their healthcare provider before adding any new skincare product, just to stay on the safe side.

Caffeine Carboxyloyl Sh-Decapeptide-1 is not known to cause photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended, as with any routine. The ingredient also plays well with most common actives such as niacinamide, hyaluronic acid and gentle antioxidants.

Potential Side Effects/Adverse Reactions

Reactions to topical Caffeine Carboxyloyl Sh-Decapeptide-1 can vary from person to person. The effects listed below are only potential outcomes and are not expected for the average user when the ingredient is properly formulated and applied.

  • Mild redness or warmth at the application site
  • Temporary tingling or slight stinging, especially on freshly exfoliated skin
  • Itchiness linked to individual sensitivity to caffeine or peptides
  • Rare allergic response resulting in hives or swelling
  • Eye irritation if product accidentally gets into the eyes

If any of these reactions occur discontinue use and seek medical advice if symptoms do not calm down quickly.

Comedogenic Rating

Rating: 1 (very low likelihood of clogging pores)

Caffeine Carboxyloyl Sh-Decapeptide-1 is highly water soluble and used at low concentrations, so it does not form heavy films on the skin that might trap oil or debris. Its peptide part is readily absorbed and the caffeine derivative is lightweight, both factors that keep it from blocking follicles. For these reasons the ingredient earns a score of 1 rather than a perfect 0, mainly to reflect that individual skin reactions can never be ruled out entirely.

It is generally suitable for people prone to acne or breakouts.

Formulas that combine this molecule with thick occlusive oils or waxes could still feel rich for very oily skin, so product texture matters more than the ingredient itself.

Summary

Caffeine Carboxyloyl Sh-Decapeptide-1 works primarily as a skin conditioning agent. The caffeine portion perks up microcirculation helping the complexion look awake while the decapeptide segment supports a smoother, more hydrated surface by signaling skin to maintain its natural resilience. Together they leave skin feeling toned comfortable and refreshed.

While not as mainstream as niacinamide or vitamin C this hybrid molecule has carved out a niche in modern eye serums and targeted firming products where brands look for multitasking yet gentle actives.

Current evidence shows it is well tolerated with a very low risk of irritation or pore clogging when properly formulated. As with any new skincare addition perform a quick patch test and monitor your skin’s response before applying it more broadly.

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