Cetamido Lysinamido Polyaspartic Acid: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Cetamido Lysinamido Polyaspartic Acid?

Cetamido Lysinamido Polyaspartic Acid is an organic compound made by joining fatty acid derived from coconut oil with the amino acids lysine and aspartic acid. The result is a gentle, water-friendly molecule that loves both oil and water, which lets it blend smoothly into creams and lotions.

The idea of linking plant oils with amino acids started in the late 1990s when makers of skin care were looking for softer, greener alternatives to mineral oil based ingredients. After years of lab work formulators found that adding a long fatty chain like cetyl to a short chain of natural amino acids produced a conditioner that felt silky without leaving a greasy film. This discovery led to the launch of Cetamido Lysinamido Polyaspartic Acid which first appeared in high-end Japanese moisturizers and later spread to global brands.

The ingredient is made through a few simple steps. First coconut oil is split to isolate cetyl groups. At the same time lysine and aspartic acid are fermented from plant sugars. The fatty chain and the amino acids are then linked in a water bath at moderate heat. After filtering and drying the finished powder is ready for use.

You will now find Cetamido Lysinamido Polyaspartic Acid in face masks, hydrating serums, anti aging creams, after sun gels and soothing eye treatments where a smooth light feel is desired.

Cetamido Lysinamido Polyaspartic Acid’s Cosmetic Benefits/Uses

The main role of this ingredient is skin conditioning which means it helps skin feel soft smooth and healthy. By holding water on the surface and supporting the natural skin barrier it boosts moisture levels, calms rough patches and gives formulas a silky slip that makes them pleasant to spread.

Who Can Use Cetamido Lysinamido Polyaspartic Acid

This conditioner is gentle enough for almost every skin type. Dry and mature skin appreciate the added moisture, while normal and combination skin enjoy the silky texture without a heavy feel. Even oily and acne prone users typically tolerate it because the molecule is lightweight and rinses clean. Only those with a known allergy to coconut derived fatty chains or the amino acids lysine or aspartic acid might need to avoid it, though such sensitivities are uncommon.

The ingredient is produced entirely from plant sources so it suits both vegetarians and vegans, and no animal by products are used during processing.

Current research shows no hormonal or systemic effects, so pregnant or breastfeeding women can generally use products containing Cetamido Lysinamido Polyaspartic Acid; however this is not medical advice and anyone expecting or nursing should show the full product list to a healthcare professional before adding it to a routine.

Cetamido Lysinamido Polyaspartic Acid does not increase photosensitivity and can be worn day or night without raising sun burn risk. It also plays well with common actives like retinol, niacinamide and vitamin C, making it a flexible choice in multi step regimens.

Potential Side Effects/Adverse Reactions

Side effects from topical use of Cetamido Lysinamido Polyaspartic Acid differ from person to person. The points below outline potential reactions, but most people will not notice any problems when the ingredient is formulated and used correctly.

  • Mild redness or itching in individuals with very sensitive skin
  • Transient stinging if applied to freshly exfoliated or broken skin
  • Rare allergic contact dermatitis in those allergic to coconut derivatives or specific amino acids
  • Occasional breakout or pore congestion in users already prone to acne when combined with very rich occlusive formulas

If any adverse reaction occurs stop using the product immediately and seek advice from a qualified healthcare provider.

Comedogenic Rating

Rating: 1/5

Cetamido Lysinamido Polyaspartic Acid carries a low risk of clogging pores because its molecule is lightweight and partly water loving so it does not linger on the skin or form a heavy film. In finished products it is usually present at modest levels which further reduces the chance of buildup. As long as it is not paired with thick occlusive oils most acne prone users should find it compatible.

Suitable for breakout prone skin, though those very sensitive to any fatty ingredient may prefer to monitor skin response when first adding it.

Keep in mind that the overall formula matters more than a single ingredient; pairing this conditioner with highly comedogenic oils or waxes could shift the final product’s pore clogging profile upward.

Summary

Cetamido Lysinamido Polyaspartic Acid is a plant derived skin conditioner that softens, smooths and boosts surface hydration by linking a coconut fatty chain with the amino acids lysine and aspartic acid. Its hybrid oil-and-water structure lets it sit comfortably on the skin, reinforcing the barrier while leaving a silky feel without heaviness.

Although it first appeared in niche Japanese creams it has steadily made its way into mainstream moisturizers, masks and serums because formulators value its gentle touch and vegan origin. You may not spot it in every pharmacy brand yet but its presence is growing as demand for greener alternatives rises.

Current safety data show very low irritation and no systemic concerns, which makes it a reliable choice for most routines. As with any new product a quick patch test is a smart step to confirm personal compatibility before full-face application.

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