Chlorobutanol: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Chlorobutanol?

Chlorobutanol is the common name for 1,1,1-trichloro-2-methyl-2-propanol, an alcohol molecule that carries three chlorine atoms. Those chlorine atoms give it strong antimicrobial power, which is why the ingredient first drew attention in the early 1900s when pharmacists used it to keep eye drops stable. Today formulators still rely on the same ability to stop unwanted microbes from growing in products.

The ingredient is usually made by reacting chloroform with acetone in the presence of a base. The result is a white crystalline powder that is easily dissolved in oils or a mix of oil and water, letting it slip into many kinds of beauty products.

You will most often see chlorobutanol in formulas where long shelf life is crucial or where the product is likely to sit open in a warm bathroom. It turns up in face creams, sheet masks, anti-aging serums, eye gels, scalp treatments, and even some specialty makeup like cream concealers or potted eyeliners. Its job is always the same: keep the product fresh and safe for use until the last drop.

Chlorobutanol’s Cosmetic Benefits/Uses

In cosmetics chlorobutanol serves a single but vital purpose: it is a preservative. By stopping bacteria, mold, and yeast from multiplying it helps products stay stable, smell fresh, and remain gentle on the skin for their full shelf life. Without an effective preservative a cream or serum could spoil within weeks, leading to changes in texture or color and, more importantly, the risk of irritation or infection. Chlorobutanol helps prevent that, giving both brands and users peace of mind.

Who Can Use Chlorobutanol

Most skin types can tolerate chlorobutanol because it is used at very low levels and is not known to clog pores or cause excess dryness. Normal, oily and combination skin usually handle it well. Those with very sensitive or reactive skin should stay alert to any sign of irritation since any preservative can occasionally cause redness or a slight sting.

The ingredient is synthetically produced from petrochemical sources, so it contains no animal derivatives and is considered suitable for both vegans and vegetarians.

Current data does not link chlorobutanol in topical products to risks during pregnancy or breastfeeding, but safety research is limited. This information is not medical advice and anyone who is pregnant or nursing should get personal guidance from a doctor before adding new skincare products.

Chlorobutanol does not increase photosensitivity, so it will not make skin more prone to sunburn. It is also fragrance free and has a neutral scent, making it unlikely to clash with other actives or perfumes in a formula.

Potential Side Effects/Adverse Reactions

Side effects from topical chlorobutanol can vary from person to person. The issues listed below are only potential reactions and are unlikely to occur for most users when the ingredient is used correctly in a well formulated product.

  • Mild skin irritation such as redness or a transient burning sensation
  • Contact dermatitis in those with an existing preservative allergy
  • Eye stinging or watering if the product enters the eyes
  • Rare allergic swelling or hives

If you experience any of the above effects stop using the product and seek advice from a healthcare professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 0/5

Chlorobutanol is used at very low concentrations and does not have an oily or waxy texture that could block pores. Its small molecular size and rapid evaporation from skin further lower any chance of clogging. Because of this it earns a solid non-comedogenic score.

Suitable for acne-prone or breakout-prone skin.

No studies show it altering sebum production or worsening blackheads. Its role as a preservative means it sits in the background rather than forming a film on the skin, keeping the risk of congestion minimal.

Summary

Chlorobutanol is a preservative that keeps cosmetics free of bacteria mold and yeast by disrupting their cell walls. It works reliably at low levels which helps products stay fresh stable and pleasant to use.

The ingredient is less famous than big names like phenoxyethanol or parabens yet it still shows up in a range of creams serums and eye products where formulators need an extra antimicrobial boost.

Used within recommended limits it is considered safe for most users with only rare reports of irritation or allergy. As with any new skincare step it is smart to do a small patch test first to make sure your skin agrees with it.

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