Chloroform: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Chloroform?

Chloroform, also called trichloromethane, is a clear colorless liquid that carries a mild sweet smell. Chemically it belongs to the family of chlorinated hydrocarbons and is made up of one carbon atom bonded to one hydrogen and three chlorine atoms. Early in the 19th century it was first prepared by chemists who reacted chlorine with ethanol or acetone, and it soon found its way into many industries. While it is best known for its past medical use as an anesthetic, its role in cosmetics is far more specific and controlled.

Modern production of chloroform usually starts with methane, which is treated with chlorine gas under heat and light. This reaction substitutes three hydrogen atoms with chlorine atoms, giving the trichloromethane structure. The resulting liquid is then purified through distillation to remove unwanted by-products.

In cosmetic manufacturing chloroform is valued as a powerful solvent that can help dissolve certain ingredients that do not mix well with water. For this reason small, tightly regulated amounts may be used during the production of face masks, specialty serums, some exfoliating treatments and occasional anti-aging formulations. It is rarely found in over-the-counter moisturizers or cleansers and when it is present it is typically removed or left only in trace levels by the end of processing.

Chloroform’s Cosmetic Benefits/Uses

Within the scope of skincare formulations chloroform serves one main purpose.

As a solvent chloroform can dissolve oils, waxes and certain active ingredients that are hard to mix. This helps chemists create a smooth uniform product so that each application delivers the same level of actives. By keeping ingredients evenly dispersed it can also improve the texture and stability of the final formula, giving consumers a product that feels consistent from the first use to the last.

Who Can Use Chloroform

Because chloroform acts as a processing solvent and rarely remains in meaningful amounts in finished products, it is generally considered neutral toward specific skin types. Normal, oily, dry and combination skin should not react differently as long as the final formula is balanced. Sensitive or compromised skin might be more prone to irritation if trace levels are present, so those users may prefer to choose products that list alternative solvents.

Chloroform is a fully synthetic ingredient produced from methane or other petrochemical sources, so it is suitable for vegans and vegetarians. No animal-derived materials are involved at any stage of its manufacture.

Pregnant or breastfeeding individuals should approach any product that may contain residual chloroform with caution. While topical exposure is usually minimal, unborn and nursing babies are more vulnerable to chemicals. This is not medical advice; anyone who is pregnant or nursing should show the full ingredient list to a qualified healthcare provider before use.

Chloroform does not increase photosensitivity and has no known effect on how skin responds to sunlight. It is non-comedogenic by nature and does not clog pores, although the overall formulation could still impact breakout-prone skin.

Potential Side Effects/Adverse Reactions

Reactions to topical chloroform vary from person to person. The effects listed below are possible outcomes, not expected outcomes, and most users should not notice any problems when products are made and used correctly.

Skin irritation – mild stinging or burning can occur, especially on sensitive or broken skin

Dryness or flaking – its solvent nature can strip surface lipids leaving the area parched

Redness or rash – contact dermatitis may develop in those with heightened chemical sensitivity

Sensitization over time – repeated exposure could make skin more reactive to chloroform or similar solvents

If any of these side effects appear stop using the product and speak with a healthcare professional for further guidance.

Comedogenic Rating

Rating: 0/5

Chloroform does not contain fatty acids, oils or waxes that can block pores, so its likelihood of causing comedones is virtually zero. Because it usually serves only as a processing solvent and is largely removed from the finished product, any residue is far too low to create pore congestion.

For people prone to acne or frequent breakouts this ingredient is generally considered safe, provided the overall formula is well balanced and gentle.

If a product contains other heavy emollients or occlusives the finished blend, not chloroform itself, may still pose a clogging risk.

Summary

Chloroform is used in cosmetic labs as a strong solvent that dissolves stubborn oils, waxes and certain actives, helping chemists achieve smooth uniform textures. By breaking down hard to mix ingredients it promotes even distribution and consistent performance in masks, serums and some anti-aging treatments.

Its use is niche rather than mainstream because stricter safety regulations and the rise of greener alternatives have reduced its popularity. Most everyday skincare products rely on other solvents that present fewer regulatory hurdles.

When residues are kept within legal limits topical exposure is considered low risk, though sensitive or compromised skin may still experience irritation. As with any new product perform a small patch test to confirm personal tolerance before full use.

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