Chlorotrifluoropropene: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Chlorotrifluoropropene?

Chlorotrifluoropropene, listed on ingredient labels as trans-1-chloro-3,3,3-trifluoropropene-1, is a small fluorinated molecule created in a lab from petrochemical feedstocks. Chemists start with propene, add chlorine and fluorine atoms in controlled steps, then purify the result to cosmetic grade so it is free of harsh residues. The compound first appeared in the 1990s as an environmentally friendlier refrigerant and industrial solvent. Its low boiling point, high stability and clean evaporation profile soon caught the attention of cosmetic formulators looking for light, fast-drying solvents that leave no residue or odor on skin or hair.

Today you can find chlorotrifluoropropene in a range of products where rapid drying and a smooth finish matter. These include facial mists, makeup-setting sprays, aerosol hair sprays, quick-dry nail polishes, some cream-to-powder foundations, lightweight sunscreens and specialty cleansers. In each case it helps disperse pigments or active ingredients evenly while flashing off in seconds to leave the final film thin, uniform and comfortable.

Chlorotrifluoropropene’s Cosmetic Benefits/Uses

In beauty formulas chlorotrifluoropropene serves one clear purpose that brings several practical perks.

Solvent: Its job is to dissolve other ingredients such as resins, polymers or UV filters so they spread evenly when sprayed or applied. Because it evaporates quickly at room temperature it shortens drying time, keeps textures light and reduces the need for heavier alcohols. The result is a smooth, even layer of product without tackiness or streaks, helping makeup set neatly, hair styles lock in place and nail polish dry faster.

Who Can Use Chlorotrifluoropropene

This solvent is considered non-comedogenic and inert so it suits most skin types including dry, oily, combination and sensitive. Because it evaporates almost instantly it does not linger on the skin to clog pores or upset the barrier. People with extremely reactive or allergy-prone skin should still scan the full formula since other ingredients may pose a problem even if chlorotrifluoropropene itself is unlikely to.

The molecule is synthesized entirely from petrochemical sources without animal or bacterial components which makes it acceptable for vegans and vegetarians.

Current safety data show no evidence that topical use poses special risks during pregnancy or while breastfeeding. Even so this is not medical advice and anyone who is pregnant or nursing should have a doctor review their skincare routine before use to be safe.

Chlorotrifluoropropene does not absorb UV light so it does not cause photosensitivity. It is also odorless and free of common allergens such as fragrances and preservatives, a plus for those avoiding sensitizers.

Potential Side Effects/Adverse Reactions

Reactions to topical chlorotrifluoropropene differ from person to person. The points below outline potential side effects yet they are rare when the ingredient is used correctly in well-formulated products.

  • Transient stinging if applied to broken or freshly exfoliated skin
  • Mild eye irritation if the aerosol mist is sprayed directly into eyes
  • Contact dermatitis in individuals with a specific allergy to fluorinated solvents
  • Inhalation discomfort such as coughing when used in a poorly ventilated space

If you notice irritation, redness or any persistent discomfort discontinue use and consult a healthcare professional.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Chlorotrifluoropropene flashes off the skin within seconds so it leaves no film that could block pores. It is chemically inert, carries no oils or waxes and is used at low levels in finished products, all of which keep its pore-clogging potential at virtually zero.

Suitable for acne-prone or breakout-prone skin.

Because it evaporates so quickly any residue from other formula components, not the solvent itself, is what might influence comedogenicity so judge the full product rather than this single ingredient.

Summary

Chlorotrifluoropropene is a lightweight solvent that dissolves resins, polymers and filters then evaporates fast to leave a smooth even film. Its quick dry time helps makeup set, nail polish harden and hair sprays feel light without stickiness.

It remains a niche ingredient mostly found in aerosol or quick-dry formats rather than everyday creams or lotions, but formulators who need ultra-fast evaporation value it highly.

Current data show it is low toxicity, non-sensitizing and non-comedogenic when used as directed. As with any new cosmetic it is wise to patch test a product containing chlorotrifluoropropene before full use to ensure personal compatibility.

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