Cholesteryl Macadamiate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Cholesteryl Macadamiate?

Cholesteryl Macadamiate is a lipid created by joining macadamia seed fatty acids with cholesteryl esters. The macadamia tree grows in Australia and its nuts are pressed to obtain an oil rich in palmitoleic and oleic acids. Chemists bond a portion of this oil to cholesterol through a controlled esterification process. The result is a silky wax-like substance that is more stable and spreadable than plain plant oil.

The idea of linking plant oils to cholesterol first appeared in the 1990s as brands looked for ways to mimic the skin’s own protective barrier. Cholesteryl Macadamiate quickly gained notice because its structure resembles the natural lipids found in human sebum, allowing it to blend smoothly with the skin’s surface.

Today the ingredient is made in modern cosmetic labs. After macadamia oil is refined, it is reacted with cholesterol under gentle heat, then purified into soft flakes or a viscous liquid that is easy to mix into creams and serums.

You will most often see Cholesteryl Macadamiate in moisturizers, anti-aging creams, body lotions, lip balms, hair masks and rich overnight treatments where a plush, comforting feel is desired.

Cholesteryl Macadamiate’s Cosmetic Benefits/Uses

This multi-tasking lipid supports both the feel and performance of many formulas.

  • Skin conditioning – helps soften and smooth the skin surface while reinforcing its natural barrier so moisture stays in longer
  • Emollient – gives creams and balms a cushiony glide that makes application pleasant and leaves a velvety finish
  • Viscosity controlling – thickens emulsions just enough to prevent separation, allowing products to have a stable, luxurious texture without heavy waxes

Who Can Use Cholesteryl Macadamiate

Thanks to its skin-mimicking lipids this ingredient suits most skin types, especially dry, mature and normal skin that need extra cushioning. Combination and mildly oily skin can usually tolerate it too but very oily or acne-prone complexions might find the texture a bit rich and should use it sparingly.

Because the cholesterol portion is typically sourced from lanolin or other animal-derived materials Cholesteryl Macadamiate is not considered vegan or vegetarian friendly. Brands that claim a plant origin should be checked carefully if this point matters to you.

The ingredient is not known to interfere with pregnancy or breastfeeding. It sits on the skin’s surface rather than entering the bloodstream, yet this is not medical advice and anyone who is pregnant or nursing should clear all skincare choices with a doctor first.

Cholesteryl Macadamiate does not make skin more sensitive to sunlight so no extra daytime precautions are needed beyond normal SPF use.

Potential Side Effects/Adverse Reactions

Responses to topical Cholesteryl Macadamiate differ from person to person. The points below outline potential side effects, though they are uncommon when the ingredient is used at standard cosmetic levels.

  • Mild pore clogging or breakouts on very oily or acne-prone skin
  • Rare allergic contact dermatitis, especially in those allergic to lanolin
  • Transient redness or stinging if applied to broken or highly sensitised skin

If any irritation or unexpected reaction occurs stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 2/5

Cholesteryl Macadamiate mimics the skin’s own lipids so it generally absorbs without leaving a thick film. Its mainly monounsaturated fatty acids spread easily which keeps pore blockage low. However it is still an oil-derived ester, and on very oily or acne-prone skin the added lipids can sometimes tip the balance toward congestion.

Most dry, normal and combination skins use it without problems, while breakout-prone users may prefer lighter formulas or limit use to smaller areas like lips or eye contours.

The risk also depends on concentration: products that place it near the end of the ingredient list are less likely to clog pores than rich balms where it plays a starring role.

Summary

Cholesteryl Macadamiate acts as a skin conditioner, emollient and viscosity controller. By bonding macadamia fatty acids to cholesterol it imitates the natural barrier, smooths rough patches, locks in water and lends creams a plush glide without waxy heaviness.

While not a mainstream buzzword it enjoys steady popularity in high-end moisturisers, lip balms and overnight masks that aim for a luxurious feel.

It has a strong safety profile with few reported reactions, yet everyone’s skin is unique so patch testing a new product that features Cholesteryl Macadamiate is always a smart move.

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