Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate): What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
Share:
Inside this article:

All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate)?

Cocamide Dea Sesqui (Cocoyl Methyl Beta-Alaninate) is a blend of monoesters and diesters created when cocamide DEA, a fatty substance from coconut oil, reacts with cocoyl methyl beta-alanine, an amino acid-based compound. The result is a surfactant that mixes the conditioning feel of coconut-derived ingredients with the mild cleansing power of amino acid chemistry.

Manufacturers first explored this type of coconut and amino acid hybrid in the late 20th century as consumers looked for gentler alternatives to harsh sulfate cleansers. Today it is produced in controlled reactors where the two starting materials are heated, combined and then purified to meet cosmetic grade standards.

You are most likely to spot Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) on the label of shampoos, body washes and facial cleansers but it also shows up in moisturizers, hand soaps, shaving foams, hair masks and baby care formulas where a soft touch and balanced foam are needed.

Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate)’s Cosmetic Benefits/Uses

This multi-tasking ingredient supports a formula in several helpful ways:

  • Humectant: Draws water from the air to the skin surface so products feel more hydrating and leave skin or hair less dry
  • Emollient: Smooths rough areas by filling in tiny gaps on the skin or hair cuticle delivering a softer, silkier feel
  • Cleansing: Loosens dirt oil and buildup allowing them to rinse away easily without stripping natural moisture
  • Emulsifying: Helps oil and water stay evenly mixed which keeps creams stable and prevents separation in liquid washes

Who Can Use Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate)

Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) is generally gentle enough for most skin types including normal, dry, combination and oily skin. Its humectant quality adds light hydration while the mild surfactant action cleans without over stripping, so even sensitive skin can often tolerate it. Those with very reactive or eczema-prone skin should still watch for redness or stinging because any surfactant can sometimes disrupt a fragile barrier.

Because the ingredient is sourced from coconut fatty acids and synthesized amino acids, it is considered suitable for vegans and vegetarians. No animal by-products are involved in typical manufacturing and no animal testing is required for its use in many regions that follow cruelty-free standards.

Current safety data show no specific risks for pregnant or breastfeeding women when the ingredient is used topically in rinse off or leave on cosmetics. This is not medical advice, and anyone who is expecting or nursing should review all personal care products with a qualified healthcare provider to be extra cautious.

Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) does not cause photosensitivity so there is no special need to avoid sunlight after application. It also plays well with most other common skincare actives and does not interfere with sunscreen efficacy.

Potential Side Effects/Adverse Reactions

Reactions to topical Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) differ from person to person. The following is a list of potential side effects, yet most users will not experience them when the ingredient is correctly formulated and used as directed.

  • Mild skin irritation – Redness or a slight burning sensation can occur, especially on compromised or very sensitive skin
  • Contact dermatitis – Rare allergic response marked by itching, rash or swelling
  • Eye irritation – Temporary stinging if the product accidentally gets into the eyes
  • Scalp dryness – Overuse in shampoos may strip natural oils leading to flakiness for some people
  • Nitrosamine contamination concern – Trace levels of nitrosamines may form if the formula also contains nitrosating agents, though reputable manufacturers control for this

If any uncomfortable reaction develops stop using the product and seek advice from a medical professional.

Comedogenic Rating

Rating: 1 / 5. Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) is mainly a cleansing and emulsifying agent with a light fatty backbone. It rinses off easily, does not linger in pores and contains no heavy oils that typically clog skin. Because of that, it poses very little risk of causing blackheads or breakouts. Most acne-prone users can use products containing this ingredient without trouble, though very oily skin might prefer it in wash-off formulas rather than rich creams. There are no reports of the ingredient worsening existing acne.

Summary

Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) works as a humectant that attracts water to the surface, an emollient that smooths rough texture, a gentle cleanser that lifts dirt, and an emulsifier that keeps oil and water blended. It does this by pairing coconut-derived fatty chains with an amino acid head, giving it both oil-loving and water-loving parts that cooperate inside a formula.

The ingredient sits in the mid-tier of popularity: common enough to appear in many shampoos body washes and mild facial cleansers, but not yet a buzzword on front labels. Formulators value it for its softness and versatility even if most shoppers are not familiar with the name.

Current safety reviews show it is low risk for the average user with only rare irritation reports. Still, skin is personal so it is smart to try any new product containing Cocamide Dea Sesqui(Cocoyl Methyl Beta-Alaninate) on a small area first and watch how your skin responds.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search