What Is Cyclic Lysophosphatidic Acid?
Cyclic Lysophosphatidic Acid is a lipid-based molecule that comes from phospholipids found in natural cell membranes. Most cosmetic makers source it from plant ingredients such as soy lecithin or from egg yolk, then refine and purify it for skin care use. Chemists first studied it in the 1990s while exploring how skin cells communicate, and its strong water-binding skill soon caught the attention of beauty labs looking for fresh hydrators.
To create the cyclic form used in creams scientists start with regular lysophosphatidic acid, then run it through a controlled reaction that bends the open chain into a closed ring. This ring structure improves stability so the ingredient can sit in a jar without breaking down.
You will usually spot cyclic lysophosphatidic acid in products that focus on moisture and smooth feel. It shows up in lightweight serums, leave-on masks, daily moisturizers, anti aging creams and after-sun gels where an extra shot of hydration helps plump the skin’s surface.
Cyclic Lysophosphatidic Acid’s Cosmetic Benefits/Uses
In skin care formulas this ingredient plays one key role.
As a humectant it draws water from the air and the deeper layers of the skin toward the surface, boosting immediate hydration and giving a soft, supple finish. This moisture pull can also make other active ingredients spread more evenly and feel more comfortable on the skin.
Who Can Use Cyclic Lysophosphatidic Acid
This humectant is gentle enough for most skin types including dry, balanced, combination and oily skin, since it adds water without leaving a greasy film. Sensitive skin users usually tolerate it well because it is not acidic or highly reactive, though formulas that pair it with strong actives could still cause irritation from those other ingredients. There are no known reasons for acne-prone or mature skin to avoid it.
Whether the ingredient is vegan depends on its source. When manufacturers derive it from soy lecithin or other plant phospholipids it is suitable for both vegetarians and vegans. If it comes from egg yolk it will be vegetarian friendly but not vegan. Brands rarely specify origin on the label so strict vegans may wish to check with the company.
No data links cyclic lysophosphatidic acid to hormonal disruption or developmental concerns, so it is generally viewed as safe for people who are pregnant or breastfeeding. Still, this is not medical advice and anyone expecting or nursing should run any product past a doctor before adding it to their routine.
The ingredient does not increase photosensitivity, so it can be used morning or night without raising the risk of sunburn. As always daily sunscreen is recommended for overall skin health.
Potential Side Effects/Adverse Reactions
- Mild redness or stinging in very sensitive skin
- Transient tight or dry feeling if layered with multiple strong humectants that pull water out too quickly
- Allergic contact dermatitis in individuals with a specific phospholipid allergy
- Breakouts if the finished product contains occlusive oils or waxes that trap moisture and sebum
If any unexpected irritation or discomfort occurs stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0–1 out of 5. Cyclic Lysophosphatidic Acid is a small, water-loving molecule that dissolves easily in the watery phase of a formula and does not form an oily film on the skin. Because it boosts hydration without clogging pores it sits at the very bottom of the comedogenic scale.
That low rating means the ingredient is generally suitable for people who are prone to acne or frequent breakouts. Only the other components of the finished product, such as heavy oils or waxes, are likely to influence pore-clogging potential.
As a side note its quick absorption can actually help thin out richer cream bases, making them feel lighter and less likely to sit on the surface of the skin.
Summary
Cyclic Lysophosphatidic Acid is used in cosmetics mainly as a humectant, pulling water toward the upper layers of the skin to give a plump smooth look. Its ring-shaped structure keeps it stable so it can keep delivering moisture over time.
It is still a niche ingredient compared with big-name hydrators like glycerin or hyaluronic acid, but formulators appreciate its light feel and compatibility with both simple hydrating gels and high-performance anti-aging creams.
Current research and industry reports consider it safe for topical use with a very low risk of irritation or pore blockage. As with any new skincare product patch testing on a small area first is a smart precaution.