Cyclohexyl Hydroxybutyramide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 24, 2025
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All information on this page is verified using publicly available nomenclature standards and reference materials from The Personal Care Products Council (PCPC) and the European Commission's CosIng database. Our analyses are based on technical data from these sources to ensure accuracy and reliability.

What Is Cyclohexyl Hydroxybutyramide?

Cyclohexyl Hydroxybutyramide is a lab made ingredient that combines a cyclohexyl group with a small fatty acid called hydroxybutyric acid, ending up as a soft solid that dissolves well in common cosmetic oils. It was first explored in the late 1990s when formulators were searching for gentler alternatives to heavy waxes and silicones. The compound is produced through a simple amidation step where cyclohexylamine reacts with 4 hydroxybutyric acid under controlled heat, then purified to remove any leftover starting materials. Because it brings a silky touch without feeling greasy it soon found its way into skin creams, hair masks, rinse off conditioners, leave in serums, body lotions, hand creams and overnight anti aging treatments.

Cyclohexyl Hydroxybutyramide’s Cosmetic Benefits/Uses

Here is how this multitasker helps a formula perform better

  • Hair conditioning – coats the hair shaft in a thin layer that smooths cuticles which makes strands feel softer, look shinier and stay tangle free after washing
  • Skin conditioning – forms a breathable film on the skin surface that reduces water loss so skin feels hydrated longer and appears plumper
  • Emollient – fills in tiny gaps on the skin and hair surface giving an instantly soft, silky finish and improving spreadability of the product

Who Can Use Cyclohexyl Hydroxybutyramide

Cyclohexyl Hydroxybutyramide suits most skin types including dry, normal and combination skin because it delivers moisture without clogging pores or leaving a heavy residue. Very oily or acne prone users may still tolerate it well thanks to its light texture though individual experiences can vary if multiple rich ingredients are present in the same formula.

The ingredient is fully synthetic and the starting materials come from petrochemical or plant based feedstocks rather than animal sources so it is appropriate for vegans and vegetarians.

No published data link Cyclohexyl Hydroxybutyramide to problems during pregnancy or breastfeeding. It is generally viewed as low risk in rinse off and leave on cosmetics but this is not medical advice. Expectant or nursing mothers should show the full ingredient list of any product they plan to use to their doctor to be extra safe.

The molecule does not absorb UV light or make skin more sensitive to the sun so it is not considered photosensitising. It also performs well on color treated hair because it is non stripping and silicone free.

Potential Side Effects/Adverse Reactions

Responses to topical Cyclohexyl Hydroxybutyramide differ from person to person. The points below outline potential side effects yet most users will not run into these issues when the ingredient is included at typical cosmetic levels and the product is manufactured correctly.

  • Mild skin irritation – a small number of users may notice temporary redness itching or stinging especially on broken or highly sensitive skin
  • Contact allergy – rare allergic reactions have been reported with amide structures which can lead to rash or swelling
  • Eye irritation – if a product accidentally gets into the eyes it can cause watering and discomfort until rinsed out
  • Hair buildup – overuse in leave in products could weigh down very fine hair leaving it flat or greasy looking

If any negative effect occurs stop using the product and seek advice from a qualified healthcare professional or dermatologist.

Comedogenic Rating

Rating: 1/5. Cyclohexyl Hydroxybutyramide forms a very thin breathable film that does not trap much oil or debris in pores. Its molecular size is moderate and it is typically used at low levels so it is unlikely to harden inside follicles or create blockages. This makes it generally suitable for people who are prone to acne or breakouts. Lab tests also show it has low viscosity and spreads quickly which further reduces the chance of pore congestion. Only when combined with heavier waxes or oils could the overall formula become more comedogenic so always assess the full ingredient list.

Summary

Cyclohexyl Hydroxybutyramide softens hair, conditions skin and acts as a light emollient by laying down a smooth film that traps moisture yet feels weightless. Its balanced structure lets it glide on easily, fill in surface gaps and tame frizz without the greasy feel associated with silicones or butters. While not as famous as shea butter or dimethicone it has gained steady popularity among formulators who want a vegan friendly lightweight alternative that still delivers a silky finish. Safety reviews rate it as low risk with very rare irritation or allergy reports. As with any new product a quick patch test is wise to ensure your skin or scalp agrees with the complete formula.

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