What Is Cyclohydroxyprolyl Serine?
Cyclohydroxyprolyl Serine is a lab made dipeptide that combines two amino acids, proline and serine, into a small ring-shaped molecule. The scientific name, pyrrolo[1,2-a]pyrazine-1,4-dione hexahydro-7-hydroxy-3-(hydroxymethyl), hints at its ring structure and multiple hydroxyl (OH) groups that make it naturally water loving. Although the compound itself is synthetic, the building blocks come from plant-derived or fermentation-produced amino acids, which are joined through controlled chemical reactions and then purified to cosmetic grade.
Interest in peptide ingredients took off in the early 2000s when brands began looking for gentle yet effective ways to hydrate and smooth skin. Cyclohydroxyprolyl Serine entered the scene as formulators noticed its ability to bind water and soften texture without feeling greasy. Today it is manufactured in stainless steel reactors where temperature and pH are carefully monitored, followed by filtration, concentration and drying to yield a white to off-white powder that dissolves easily in water-based systems.
You will most often spot Cyclohydroxyprolyl Serine in lightweight moisturizers, hydrating serums, sheet masks, soothing after-sun gels, anti-aging lotions and leave-on hair treatments. Its mild profile lets brands include it in products aimed at daily use or sensitive skin routines.
Cyclohydroxyprolyl Serine’s Cosmetic Benefits/Uses
This multitasking peptide brings several perks to personal care formulas
- Humectant – attracts moisture from the environment and pulls it into the upper layers of skin so the surface feels plumper and more comfortable
- Skin conditioning – smooths rough patches and helps maintain a healthy skin barrier which can improve overall tone and softness
- Emollient – fills in tiny gaps between skin cells to create a silky finish that reduces flake and dryness without a heavy or oily feel
Who Can Use Cyclohydroxyprolyl Serine
Cyclohydroxyprolyl Serine is generally friendly to all major skin types including dry, normal, combination and oily. Its light texture and water binding ability make it especially helpful for dehydrated or sensitive skin that struggles with heavier creams. Extremely acne-prone users who react to most ingredients can still find it agreeable because it is non greasy and has no known pore-clogging tendency, although individual results will vary.
The peptide is synthesized from plant sourced or fermentation derived amino acids and contains no animal by-products, so it meets vegan and vegetarian standards.
There is no data showing that Cyclohydroxyprolyl Serine crosses the skin barrier in amounts that could affect pregnancy or nursing. Current safety assessments classify it as low risk for these groups, but this is not medical advice. Anyone who is pregnant or breastfeeding should have their doctor review any skin care routine for added peace of mind.
The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. Routine daytime sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Cyclohydroxyprolyl Serine differ from person to person. The points below outline potential side effects that remain uncommon when the ingredient has been properly formulated
- Mild redness or warmth shortly after application
- Temporary stinging on very dry or broken skin
- Rare allergic contact dermatitis characterized by itching or small bumps
- Eye irritation if the product accidentally migrates into the eyes
Should you notice any of these reactions discontinue use and seek guidance from a healthcare professional
Comedogenic Rating
Rating: 0 (non-comedogenic)
Cyclohydroxyprolyl Serine is a small water soluble peptide that does not leave an oily film or settle inside pores, which is why it receives the lowest possible comedogenic score. Its humectant and skin conditioning roles rely on attracting water, not on forming heavy occlusive layers. As a result it is generally suitable for people who are prone to acne or frequent breakouts.
One thing to keep in mind is that the finished product matters. If the peptide is blended into a rich cream full of heavy butters or waxes, the overall formula could still clog pores even though Cyclohydroxyprolyl Serine itself does not.
Summary
Cyclohydroxyprolyl Serine is a lab crafted dipeptide that works as a humectant, skin conditioner and light emollient. It draws moisture to the skin, smooths rough spots and leaves a soft feel without greasiness thanks to its water loving structure and small molecular size.
While peptides like Matrixyl and copper tripeptide often steal the spotlight, Cyclohydroxyprolyl Serine enjoys quiet but steady use in hydrating serums, gels and lotions aimed at sensitive or dehydrated skin. Its non-comedogenic nature and vegan origin give formulators another gentle tool for everyday products.
Current safety evaluations show a low risk of irritation or systemic effects, making it a safe choice for most users. Still, skin can be unpredictable so it is wise to do a quick patch test whenever you try a new product that contains this ingredient.