What Is Cysteinyl Tripeptide-35?
Cysteinyl Tripeptide-35 is a lab-crafted peptide that forms when the amino acid cysteine links with a short chain of three amino acids known as Tripeptide-35. The result is a small, skin-friendly molecule that blends the sulfur-rich power of cysteine with the targeted action of a tripeptide.
The idea of joining cysteine with tiny peptides grew out of research into antioxidants and skin barrier support in the early 2000s. Chemists found that attaching cysteine to a tripeptide could boost stability and make the antioxidant easier to use in water-based formulas. Today the ingredient is made in controlled reactors where cysteine and Tripeptide-35 are combined, purified and then dried into a fine powder ready for creams and serums.
You will spot Cysteinyl Tripeptide-35 in lightweight moisturizers, mattifying lotions, sheet masks, anti-aging serums, post-sun gels and leave-on treatments aimed at oily or stressed skin.
Cysteinyl Tripeptide-35’s Cosmetic Benefits/Uses
This multitasking peptide brings several perks to modern skincare formulas
- Anti-Sebum: Helps control excess oil on the skin surface which can reduce shine and limit the look of enlarged pores
- Antioxidant: Neutralizes free radicals from pollution and UV exposure helping to keep the skin looking fresh and preventing early signs of aging
- Chelating: Binds to metal ions found in tap water and some preservatives improving formula stability and preventing metals from triggering irritation or product discoloration
- Skin Protecting: Supports the skin barrier by reinforcing natural defenses which can lead to smoother more resilient skin over time
Who Can Use Cysteinyl Tripeptide-35
Cysteinyl Tripeptide-35 is generally suitable for all skin types. Oily and combination skin often benefit the most because its anti sebum property helps keep shine in check. Dry or sensitive skin can also tolerate it well since the peptide is mild and supports the barrier without stripping moisture. At this time there are no specific skin types considered incompatible with the ingredient.
The peptide is produced entirely in a lab using amino acids, so it contains no animal derived materials. This makes it appropriate for both vegetarians and vegans.
No safety warnings have been issued for the use of Cysteinyl Tripeptide-35 during pregnancy or breastfeeding. That said, this information is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product to a qualified health professional before adding it to a routine.
The ingredient does not increase photosensitivity, so there is no heightened risk of sun related irritation when you apply it. Regular daytime SPF is still recommended as part of good skincare practice.
Potential Side Effects/Adverse Reactions
Side effects from the topical use of Cysteinyl Tripeptide-35 can vary from person to person. What follows is a list of potential reactions though most users will not experience any issues when the ingredient is properly formulated and applied.
- Mild redness or warmth some very reactive skin may flush slightly after application
- Temporary stinging or tingling usually fades within minutes and tends to occur on compromised skin barriers
- Dry patches rare but can arise if the formula contains strong accompanying solvents or alcohols
- Allergic contact dermatitis extremely uncommon but possible in individuals with peptide allergies or sulfur sensitivity
- Interaction with metal based actives its chelating action can reduce the effectiveness of copper peptide serums if layered directly together
If you notice persistent irritation stop using the product and consult a healthcare professional
Comedogenic Rating
Rating: 0 out of 5. Cysteinyl Tripeptide-35 is a small, water-soluble molecule that does not leave a greasy film or block pores, so it has no known comedogenic potential. Its use levels in formulas are typically below 2 percent and it is often paired with lightweight emulsifiers or gel bases that further reduce any pore-clogging risk. This makes it perfectly suitable for skin prone to acne or breakouts. If a product containing this peptide still causes congestion the culprit is likely another ingredient in the formula rather than the peptide itself.
Summary
Cysteinyl Tripeptide-35 delivers four main benefits: it curbs excess oil, scavenges free radicals, binds irritating metal ions and reinforces the skin barrier. It accomplishes this by combining the sulfur-rich antioxidant power of cysteine with the signal-boosting properties of a short peptide, giving skin a lightweight shield against shine, pollution and everyday stressors. Although not yet a household name, it is steadily appearing in new mattifying serums, calming gels and K-beauty sheet masks as brands look for multitasking actives that suit all skin types.
Safety studies and real-world use show a low risk of irritation or pore blockage, making it a well-tolerated choice for most users. As with any new skincare ingredient a simple patch test is still a smart move before adding it to your daily routine.