Dechloro Cyclopropylcloprostenolamide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dechloro Cyclopropylcloprostenolamide?

Dechloro Cyclopropylcloprostenolamide is a lab crafted molecule that belongs to the prostaglandin analog family. Chemically it is known as 5-Heptenamide N-cyclopropyl-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]- (5Z). In simpler terms, the structure features a cyclopentyl core with several hydroxyl groups plus a small cyclopropyl ring which together help the ingredient interact well with skin lipids.

The compound does not occur in nature. It first came on the scene in pharmaceutical research focused on eye care where prostaglandin analogs were studied for their ability to condition lashes. Chemists soon noticed the molecule’s strong resistance to oxidation and its stability in cosmetic bases, opening the door for skincare formulators looking for next-generation antioxidants.

Production starts with plant-sourced fatty acids that are converted into the cyclopentyl backbone. Stepwise reactions add the phenoxy side chain, hydroxyl groups and the cyclopropyl amide before a final purification brings the ingredient to cosmetic grade. This entirely controlled synthesis ensures consistency batch after batch.

Today Dechloro Cyclopropylcloprostenolamide is found in high-performance serums, eye creams, anti-aging moisturizers, sheet masks and leave-on treatments that aim to protect skin from environmental stressors while supporting a smoother complexion.

Dechloro Cyclopropylcloprostenolamide’s Cosmetic Benefits/Uses

This ingredient appears in formulas primarily for one key reason.

Antioxidant: Dechloro Cyclopropylcloprostenolamide neutralizes free radicals generated by UV light pollution and everyday stress. By limiting oxidative damage it helps preserve collagen, keeps the skin barrier resilient and can reduce the look of dullness over time. Formulators like that it remains active even in low concentrations so it pairs well with vitamins C and E without compromising texture or scent.

Who Can Use Dechloro Cyclopropylcloprostenolamide

Most skin types, including dry, normal, combination and oily, can tolerate this ingredient because it is lightweight and non-greasy. Those with very reactive or rosacea-prone skin should proceed slowly since prostaglandin analogs have been linked to mild redness in rare cases.

The molecule is made entirely by chemical synthesis using plant-derived starter materials, with no animal origin substances, so it is suitable for vegans and vegetarians.

Current data shows no direct risk for women who are pregnant or breastfeeding when the ingredient is used on intact facial skin. Still this is not medical advice. Anyone expecting or nursing should have their doctor review the full product before use just to be safe.

Dechloro Cyclopropylcloprostenolamide does not increase photosensitivity. Standard daytime sun protection is still advised to guard against everyday UV damage that antioxidants alone cannot block.

Potential Side Effects/Adverse Reactions

Responses to topical Dechloro Cyclopropylcloprostenolamide are highly individual. The points below outline potential effects yet most people will not notice any problems when the ingredient is formulated and used correctly.

  • Mild redness or warmth at the application site
  • Temporary itching or tingling
  • Darkening of skin where applied, especially on thinner eye area skin
  • Increased fine hair growth along the lash line or brows if product migrates
  • Allergic contact dermatitis in those sensitive to prostaglandin analogs
  • Rare eye irritation or iris color change if used too close to the eye itself

If any of these effects occur stop using the product and seek guidance from a qualified healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. Dechloro Cyclopropylcloprostenolamide is a small lightweight molecule that does not leave an oily film or create a physical barrier on the skin so it has little tendency to block pores. Its antioxidant role does not rely on heavy carriers or waxes which further keeps the clogging risk low. This makes it generally suitable for people who are prone to acne or breakouts.

Summary

Dechloro Cyclopropylcloprostenolamide is used in skincare as an efficient antioxidant that scavenges free radicals and helps defend collagen, keeping skin looking smoother and more resilient. It does this through its stable prostaglandin analog structure which allows the molecule to stay active even at low levels and in challenging formulas.

You will not see it in every drugstore product yet it is gaining traction in niche serums, eye creams and high performance moisturizers where brands want a fresh alternative to the usual vitamin based antioxidants.

Current research points to a solid safety profile with only occasional mild reactions in sensitive users. As with any new skincare ingredient a quick patch test is a smart step before adding a full size product to your routine.

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