What Is Dicaffeoyl Lysyl Hexapeptide-65?
Dicaffeoyl Lysyl Hexapeptide-65 is a lab-made peptide built from six amino acids that are linked to lysine and two caffeic acid groups. The caffeic acids give the molecule extra antioxidant power while the peptide chain helps it blend well with skin proteins. Unlike plant extracts that can vary from batch to batch this ingredient is produced in a controlled setting through solid-phase peptide synthesis. Chemists add the caffeic acid units at the final steps then purify the powder so it is ready for skin care formulas.
The ingredient first appeared in research on bio-active peptides that could mimic natural skin defenses. As studies showed it could guard skin cells from free radicals and unwanted microbes brands began adding it to premium serums and creams. Today you will most often find Dicaffeoyl Lysyl Hexapeptide-65 in moisturizers anti-aging treatments sheet masks spot treatments for rough patches and post-sun care products where an extra soothing and protective boost is welcome.
Dicaffeoyl Lysyl Hexapeptide-65’s Cosmetic Benefits/Uses
This versatile peptide offers several perks that can improve the feel and performance of many skin care products.
- Antimicrobial: Helps keep formulas fresher for longer and supports the skin’s natural barrier by discouraging growth of odor-causing or irritation-triggering microbes
- Antioxidant: Neutralizes free radicals created by pollution and UV light which can help reduce the look of premature lines and dullness
- Humectant: Draws water into the outer skin layers giving a plumper smoother appearance and improving product spreadability
- Skin Conditioning: Softens and smooths the skin surface making it feel supple and comfortable after application
- Skin Protecting: Forms a light shield on the skin that helps defend against everyday environmental stress such as wind and dry indoor air
Who Can Use Dicaffeoyl Lysyl Hexapeptide-65
This peptide is generally well tolerated by all skin types including dry, oily, combination and sensitive skin because it is lightweight and non-occlusive. Those with very reactive or allergy-prone skin may still want to monitor how their skin feels since any new ingredient can trigger sensitivity in rare cases.
The ingredient is made entirely in a lab without animal components so it is suitable for vegans and vegetarians. Most suppliers also offer cruelty-free sourcing which further supports ethical preferences.
Current data shows no specific concerns for pregnant or breastfeeding women when the peptide is used topically and in the small amounts found in cosmetic formulas. This is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new products to their routine just to be safe.
Dicaffeoyl Lysyl Hexapeptide-65 does not increase photosensitivity so daily sunscreen habits remain unchanged. The peptide layers well with common actives like niacinamide, hyaluronic acid and non-exfoliating antioxidants which makes it easy to slot into most regimens.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Dicaffeoyl Lysyl Hexapeptide-65 can vary from person to person. The issues listed below are only potential outcomes and are unlikely for the average user when the ingredient is formulated and used correctly.
- Mild redness or flushing shortly after application
- Temporary tingling or warmth on very sensitive skin
- Itchiness or small hives indicating an allergic response
- Dry patches if the product also contains high levels of alcohol
- Interaction irritation when layered immediately with strong exfoliating acids or retinoids
If any discomfort or visible reaction occurs stop using the product and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Dicaffeoyl Lysyl Hexapeptide-65 is a water-soluble peptide with a small molecular size that does not leave an oily residue or form a heavy film on the skin. Because it does not add excess oil or clog pores it earns a non-comedogenic score of 0. This makes it a safe pick for people who are prone to acne or frequent breakouts. As a bonus its mild antimicrobial action can even support a clearer complexion by limiting surface bacteria.
Summary
Dicaffeoyl Lysyl Hexapeptide-65 acts as an antioxidant humectant antimicrobial skin conditioner and light protective shield. The caffeic acid parts mop up free radicals while the peptide chain pulls in moisture and blends smoothly with skin proteins. Together these actions help defend against daily stress keep skin comfortably hydrated and support a soft smooth finish.
The ingredient is still a niche player compared with big names like hyaluronic acid or vitamin C but it is showing up more often in targeted serums masks and post-sun gels where a gentle multi-tasker is welcome.
Safety data so far is positive with a low risk of irritation or pore clogging. Even so skin can be picky so do a quick patch test when trying any new product that lists Dicaffeoyl Lysyl Hexapeptide-65 to confirm it works for you.