What Is Digalloyl Lysyl Sh-Hexapeptide-4?
Digalloyl Lysyl Sh-Hexapeptide-4 is a lab-crafted peptide that combines a short chain of amino acids with digallic acid, a plant-derived antioxidant. The peptide part, known as Sh-Hexapeptide-4, serves as a delivery vehicle, while the digalloyl group adds extra free-radical fighting power. First explored by peptide researchers looking for stable topical antioxidants in the early 2000s, it gained attention when formulators noticed it could protect skin from daily stress and also play well with other common skincare ingredients.
Production begins with fermenting or synthesizing the base hexapeptide, then chemically linking it to a lysine molecule that has been modified with two gallic acid units. This multi-step process is carried out in a controlled lab setting to keep the peptide pure and active. The finished ingredient is a fine powder that dissolves easily into water-based cosmetic formulas.
You’ll most often spot Digalloyl Lysyl Sh-Hexapeptide-4 in anti-aging serums, light moisturizers, sheet masks and post-sun treatments where brands want a gentle yet effective antioxidant boost. Some brightening creams and pollution defense products include it too because of its ability to help shield skin from environmental stress.
Digalloyl Lysyl Sh-Hexapeptide-4’s Cosmetic Benefits/Uses
This peptide brings two main benefits to skincare formulas
- Antioxidant: Neutralizes free radicals created by UV light pollution and daily stress helping to reduce the look of dullness and early signs of aging
- Skin protecting: Forms a light barrier on the surface that supports the skin’s own defense system keeping moisture in and irritants out which can lead to smoother more resilient skin over time
Who Can Use Digalloyl Lysyl Sh-Hexapeptide-4
Because this peptide is lightweight non-comedogenic and water-soluble it suits nearly every skin type including oily combination dry and even sensitive complexions. Those with extremely reactive or highly allergic skin should still proceed carefully since any new active can trigger irritation in rare cases.
Digalloyl Lysyl Sh-Hexapeptide-4 is produced through laboratory synthesis with no animal-derived substances so it is considered suitable for both vegans and vegetarians.
No published data link this ingredient to hormone disruption or fetal risk. In theory pregnant or breastfeeding individuals can use products containing it but this is not medical advice and anyone in those groups should ask a doctor before adding new skincare to their routine.
The peptide does not increase photosensitivity and can be worn during daytime without making skin more prone to sunburn. Standard sunscreen use is still recommended as part of overall skin protection.
Potential Side Effects/Adverse Reactions
Responses to topical Digalloyl Lysyl Sh-Hexapeptide-4 can differ from person to person. The following outlines potential though uncommon issues. When manufacturers formulate correctly most users will not notice any negatives.
- Transient redness: a brief flush or warm feeling that usually subsides within minutes
- Mild stinging or tingling: more likely on freshly exfoliated or compromised skin
- Dry patches: can occur if the formula lacks sufficient emollients for very dry skin types
- Allergic contact dermatitis: rare itchy rash or swelling caused by individual sensitivity to the peptide or other formula components
- Ingredient interaction irritation: layering with strong acids or retinoids may amplify irritation for some users
If any of these reactions appear discontinue use immediately and consult a qualified healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Digalloyl Lysyl Sh-Hexapeptide-4 is a small water-soluble peptide that neither thickens nor hardens inside pores so it is highly unlikely to trigger blackheads or blemishes.
Suitable for acne-prone and breakout-prone skin.
The overall pore-clogging potential of a finished product will depend on the other ingredients in the formula so always check the full list if congestion is a concern.
Summary
Digalloyl Lysyl Sh-Hexapeptide-4 offers two key perks: it fights free radicals thanks to its digalloyl group and it helps reinforce the skin barrier through its peptide backbone. Together these actions can make skin look smoother and more resilient.
While it is not yet a household name like retinol or hyaluronic acid its presence is growing in modern lightweight serums and pollution defense creams.
Available data show it to be very safe for most users with only occasional mild irritation reported. As with any new product do a quick patch test first to be sure your skin stays happy.