Diisoamyl Malate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Diisoamyl Malate?

Diisoamyl Malate, also known as Di(3-methylbutyl)hydroxybutanedioate, is an ester made when malic acid is reacted with isoamyl alcohol, a naturally occurring alcohol found in some fruits. The result is a clear oily liquid with a faint fruity scent that blends smoothly into cosmetic bases. Chemists began exploring esters like this in the late 20th century because they noticed these light oils could soften skin without feeling greasy. Today manufacturers produce Diisoamyl Malate in modern facilities where malic acid and isoamyl alcohol are purified, combined with a catalyst then carefully heated. After the reaction is complete the mixture is washed and filtered to remove any leftovers, giving a high-purity ingredient ready for creams and lotions.

You will most often see Diisoamyl Malate in moisturizers, anti-aging serums, masks, foundations, lip products and leave-on treatments where a silky finish is essential.

Diisoamyl Malate’s Cosmetic Benefits/Uses

Formulators choose Diisoamyl Malate because it serves several helpful roles at the same time.

  • Plasticiser: It adds flexibility to film-forming products like mascaras or long-wear foundations so they move with facial expressions instead of cracking.
  • Skin Conditioning: It helps keep the skin surface soft and smooth, giving a healthy feel after application.
  • Emollient: The light oil fills in tiny gaps between skin cells which reduces roughness and leaves a supple touch without heaviness.
  • Solvent: It dissolves other ingredients such as pigments, sunscreens or active extracts ensuring an even spread and stable mix.

Who Can Use Diisoamyl Malate

Because it is a lightweight non-occlusive oil, Diisoamyl Malate generally suits dry, normal and combination skin that needs extra softness without a greasy after-feel. Oily or acne-prone skin can also tolerate it in low concentrations since it absorbs quickly, though those prone to clogged pores may prefer gel textures over richer creams containing it.

The ingredient is produced from plant-derived malic acid and isoamyl alcohol so it fits vegan and vegetarian preferences provided the finished formula is free of animal-based additives.

No data suggest that topical Diisoamyl Malate poses a specific risk during pregnancy or while breastfeeding, yet this is not medical advice. Expectant or nursing users should discuss any skincare product with their doctor before adding it to a routine just to be safe.

Diisoamyl Malate does not make skin more sensitive to sunlight and can be worn day or night without elevating the need for extra sun protection.

It is fragrance-neutral and free of common allergens like nuts gluten or soy, making it an easy add-in for people managing those sensitivities.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient vary between individuals. The effects listed below are possible but uncommon when Diisoamyl Malate is formulated and used correctly.

  • Mild skin irritation such as redness or itching in very sensitive users
  • Rare allergic contact dermatitis presenting as swelling or rash
  • Temporary stinging if applied to broken or freshly exfoliated skin
  • Worsening of breakouts in individuals highly prone to acne if used in heavy occlusive products

If you experience discomfort or any of the reactions above stop using the product and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 1/5

Diisoamyl Malate is a small lightweight ester that spreads thinly on the skin and sinks in fast. It does not form a heavy film or leave waxy residue so it rarely blocks pores. The rating sits at 1 because any oil-like substance can, in theory, add to buildup if a formula is already rich in occlusive agents, but on its own the clogging risk is very low.

Suitable for most people who are prone to acne or breakouts, especially when used in lighter lotions, serums or makeup bases.

Keep in mind that the final product’s full ingredient list and texture play a bigger role in pore clogging than this single component.

Summary

Diisoamyl Malate works as a plasticiser, skin conditioning agent, emollient and solvent. It softens cosmetic films so makeup moves with your skin, smooths rough patches by filling tiny gaps between cells, leaves a silky touch without grease and helps dissolve pigments or actives for an even blend.

The ingredient is not a household name like hyaluronic acid yet formulators appreciate its silky feel so you will spot it in a growing number of moisturizers, lip colors and long-wear foundations.

Overall safety data show very low irritation or allergy rates. When trying any new product that contains Diisoamyl Malate it is smart to run a quick patch test first to make sure your skin agrees with the full formula.

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