What Is Dimer D-Phenylalanyl Tripeptide-75?
Dimer D-Phenylalanyl Tripeptide-75 is a lab-crafted peptide that combines two identical units of the shorter chain D-Phenylalanyl Tripeptide-75. Peptides are small fragments of proteins made from amino acids. By linking two of these fragments together scientists create a dimer, which can show different or enhanced activity on skin compared with its single-chain form.
This ingredient does not come from plants or animals. It is produced through solid-phase peptide synthesis, a step-by-step process where each amino acid is added in a controlled order. After the first tripeptide is built a chemical linker joins two of them, forming the dimer. Strict purification removes any unreacted materials to meet cosmetic grade standards.
Peptide research gained traction in the 1990s as brands looked for alternatives to traditional moisturizers. Dimer D-Phenylalanyl Tripeptide-75 appeared later as labs experimented with dimerization to boost stability and activity. Today it is used by formulators seeking lightweight skin conditioners that mimic some of the skin’s own building blocks.
You will most often find this peptide in leave-on products such as anti-aging serums, lightweight lotions, eye creams and sheet masks. It can also be added to richer night creams and targeted treatments that claim to smooth texture or support the skin barrier.
Dimer D-Phenylalanyl Tripeptide-75’s Cosmetic Benefits/Uses
In skincare formulas Dimer D-Phenylalanyl Tripeptide-75 serves one main purpose.
Skin conditioning: The peptide helps the surface of the skin feel softer and more supple. By binding lightly to the outer layer it can improve the look of rough or dehydrated areas and create a smoother canvas for makeup. Its small size lets it sit comfortably in water-based serums without making the texture heavy, so products remain lightweight while still delivering a conditioned feel.
Who Can Use Dimer D-Phenylalanyl Tripeptide-75
This lab made peptide is gentle enough for all skin types, including oily, dry, combination and sensitive complexions. It is water soluble and non occlusive so it will not clog pores or leave a greasy feel, making it suitable for acne prone skin as well.
The ingredient is made entirely through synthetic chemistry with no animal derived substances at any stage of production. This means products containing it are generally considered appropriate for vegans and vegetarians provided the rest of the formula also meets cruelty free criteria.
Current safety data does not indicate any specific risks for pregnant or breastfeeding women when the peptide is used topically at cosmetic levels. Still this is not medical advice and anyone who is expecting or nursing should show the full product ingredient list to a qualified health professional before adding it to a routine.
Dimer D-Phenylalanyl Tripeptide-75 is not known to increase photosensitivity so it can be used day or night without extra sun sensitivity concerns, though daily sunscreen remains important for overall skin health. The peptide also plays well with common actives such as niacinamide, hyaluronic acid and ceramides.
Potential Side Effects/Adverse Reactions
Responses to topical Dimer D-Phenylalanyl Tripeptide-75 differ from person to person. The points below outline potential side effects yet these outcomes are uncommon when a product is well formulated and used as directed.
- Mild transient redness or warmth
- Temporary itching or tingling, especially on very sensitive skin
- Localized irritation if applied to broken or compromised skin
- Rare allergic contact dermatitis marked by persistent redness swelling or rash
- Increased stinging when layered immediately after strong exfoliating acids or retinoids
If any of these reactions occur stop using the product and seek guidance from a healthcare provider or dermatologist.
Comedogenic Rating
Rating: 0
Dimer D-Phenylalanyl Tripeptide-75 is a small water soluble molecule that does not form films or leave heavy residues on the skin. It lacks oils, waxes or long-chain fatty acids commonly linked to clogged pores, so it is classed as non-comedogenic. Because of this rating it is suitable for acne-prone skin and those who experience frequent breakouts.
The peptide is usually added at low percentages and sits comfortably in lightweight, water-based formulas, further reducing any risk of pore congestion. As with any ingredient, the final product’s full composition and texture play a larger role in comedogenicity than a single raw material.
Summary
Dimer D-Phenylalanyl Tripeptide-75 is a lab made dimeric peptide that conditions skin by binding lightly to the outer layer, helping it feel softer and appear smoother. Its small size lets formulators slip it into thin serums, eye gels and lotions without weighing them down, delivering a conditioned feel while keeping the product fresh and fast absorbing.
Although peptides have become buzzworthy in skincare, this specific dimer is still a niche player found mainly in specialized anti-aging or texture-refining lines rather than mass market launches.
Current data shows the ingredient is generally safe for all skin types with very low irritation and no comedogenic concerns. Still it is wise to patch test any new product that contains it to make sure your individual skin responds well.