Dimethoxyapigenin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dimethoxyapigenin?

Dimethoxyapigenin, also called Tricin, is a plant-based flavonoid most often extracted from rice bran, oats and certain grasses. Chemically it belongs to the flavone family and carries two methoxy groups and several hydroxyl groups that give it antioxidant potential. While scientists first studied it for the role it plays in plants, formulators noticed its skin friendly traits and began adding it to cosmetics in the last decade. Large-scale production usually starts with plant material that is soaked in a food-grade solvent, then the compound is separated and purified through filtration and gentle evaporation. After quality checks it is blended into a fine powder or liquid concentrate that can be dropped into finished products. You will mainly see Dimethoxyapigenin in anti-aging serums, soothing masks, daily moisturizers, brightening creams and after-sun products where extra defense and comfort are desired.

Dimethoxyapigenin’s Cosmetic Benefits/Uses

Below are the roles Dimethoxyapigenin plays when added to a topical formula

  • Skin conditioning – helps the surface of the skin feel softer and look smoother by supporting the natural barrier and attracting light moisture, which can leave the complexion more supple
  • Skin protecting – offers antioxidant activity that fights the stress caused by pollution and light exposure, helping to prevent early signs of aging and dullness

Who Can Use Dimethoxyapigenin

Dimethoxyapigenin is generally well tolerated by all major skin types including dry, normal, combination, oily and sensitive skin because it is lightweight and non greasy. Those with highly reactive or allergy-prone skin can still consider it since it lacks common irritants, but they should stay aware of any other ingredients in the finished product that might not agree with them.

The compound is sourced from plants like rice bran and oats and can be isolated without animal derivatives, so it is suitable for both vegetarians and vegans when purchased from manufacturers that certify a cruelty-free supply chain.

No research suggests that topical Dimethoxyapigenin is unsafe for pregnant or breastfeeding women when used in standard cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should review all skincare products with their healthcare provider to be extra cautious.

The ingredient is not known to cause photosensitivity. It does not make skin more vulnerable to sunburn, although pairing it with daily sunscreen will maximize its protective antioxidant benefits.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Dimethoxyapigenin can vary from person to person. The points below list potential issues that may occur, but they are uncommon when the ingredient is formulated and used correctly.

  • Mild redness or warmth in very sensitive individuals
  • Temporary tingling if applied to freshly exfoliated or compromised skin
  • Contact dermatitis in the rare case of an individual allergy to the compound or to other components in the formula
  • Eye irritation if the product accidentally migrates into the eyes, especially in higher concentration serums

If any unwanted reaction appears discontinue use and seek advice from a healthcare professional if symptoms persist or worsen

Comedogenic Rating

Dimethoxyapigenin has a comedogenic rating of 1.

This low score reflects its light molecular weight, absence of heavy oils or waxes and the fact that it is usually included at small percentages, all of which make pore blockage unlikely.

It is therefore considered suitable for people who are prone to acne or frequent breakouts.

No evidence points to interactions with sebum production, prescription acne treatments or other routine actives, so it can be layered comfortably in most regimens.

Summary

Dimethoxyapigenin is a botanical flavonoid that conditions skin by boosting surface softness while offering antioxidant protection that helps fend off early signs of aging.

Although it is not a household name like vitamin C or retinol, its silent rise in soothing serums, hydrating creams and after sun products shows that formulators appreciate its gentle yet effective profile.

Research and user experience suggest it is safe for nearly all skin types with minimal risk of irritation or congestion, but doing a quick patch test with any new product containing Dimethoxyapigenin is always a smart idea.

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