Dimethyl Methylglutarate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Dimethyl Methylglutarate?

Dimethyl Methylglutarate is the cosmetic name for a lab made liquid also known by its chemical title “Pentanedioic acid, 2-methyl-, 1,5-dimethyl ester.” It belongs to a small family of molecules created by adding methanol to methylglutaric acid, a process called esterification. The result is a clear, low-odor fluid that mixes well with many other ingredients.

The ingredient has no plant or animal source; it is produced in modern chemical plants where temperature and pressure are controlled to keep the material pure and stable. Since the 1990s formulators have turned to Dimethyl Methylglutarate when they needed a gentle helper solvent that would not interfere with fragrances, colorants or delicate actives.

You will most often spot it in lightweight skin serums, sheet mask essences, toners, anti-aging lotions and some aerosol hair products. Its ability to thin out thicker oils without leaving a greasy feel makes it useful in quick-drying body sprays and makeup setting mists as well.

Dimethyl Methylglutarate’s Cosmetic Benefits/Uses

In beauty formulas Dimethyl Methylglutarate serves one clear purpose.

Solvent: It helps dissolve or keep other ingredients evenly dispersed so the finished product goes on smoothly and delivers a consistent dose of actives with each use.

Who Can Use Dimethyl Methylglutarate

Because it is a lightweight solvent with a very low irritation profile Dimethyl Methylglutarate is generally suitable for all skin types including oily, combination, dry and even sensitive skin. It does not clog pores, leave residue or alter skin pH, so it rarely triggers issues for acne prone or reactive complexions.

The ingredient is fully synthetic and contains no animal derived material, which makes it appropriate for both vegans and vegetarians.

Current safety data show no specific risks for pregnant or breastfeeding individuals when the ingredient is applied topically at the low levels found in cosmetics. That said this is not medical advice. Anyone who is pregnant or nursing should review their entire skincare routine with a qualified health professional to be certain every product is suitable for them and their baby.

Dimethyl Methylglutarate does not increase the skin’s sensitivity to sunlight, so there is no special need for extra sun precautions beyond normal daily SPF use.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical application of Dimethyl Methylglutarate can vary from person to person. The points below outline potential issues yet most users will never experience them when the ingredient is used in a properly formulated product.

  • Mild skin irritation such as transient redness or warmth
  • Stinging sensation on freshly exfoliated or broken skin
  • Allergic contact dermatitis in individuals already sensitized to similar esters
  • Eye irritation if the ingredient gets into the eyes from sprays or mists
  • Respiratory discomfort when inhaled in high concentrations from aerosol products

If you experience any persistent discomfort, stop using the product immediately and consult a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Dimethyl Methylglutarate is a small, highly mobile ester that evaporates or absorbs quickly without leaving an oily film. It has no fatty chains that could block follicles, does not oxidize into pore-clogging residues and is normally used at low concentrations. For these reasons it earns a solid zero on the comedogenic scale.

Suitable for acne-prone or breakout-prone skin.

Because it thins heavier oils, formulators sometimes pair it with richer emollients to improve spreadability. Even in those blends its own presence does not raise the overall clogging risk.

Summary

Dimethyl Methylglutarate is a lab made solvent that keeps actives, fragrances and colorants evenly dispersed so products go on smoothly and deliver a uniform dose. It performs this job by dissolving both water-friendly and oil-friendly ingredients then flashing off without residue, which also helps formulas feel lighter.

The ingredient is more of a behind-the-scenes helper than a headline star so it is not especially famous, yet chemists value it for its reliability and skin-friendly profile.

Current research shows it is low risk for irritation or sensitization when used as directed. Still, skin can be unpredictable so it is wise to patch test any new product that contains it before applying all over.

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