What Is Dipeptide-18?
Dipeptide-18 is a lab-made peptide built from two small building blocks of protein, glycine and histidine. Because it is synthesized entirely in controlled laboratory settings, it is considered a synthetic ingredient rather than something extracted from plants or animals. Peptides began to gain attention in skin care in the late 1990s when researchers discovered their role in signaling pathways that help skin look smoother and more resilient. Since then, many brands have explored short, two-amino-acid chains like Dipeptide-18 for targeted benefits.
Manufacturers typically create Dipeptide-18 through a method called solid-phase peptide synthesis. In simple terms, chemists attach one amino acid at a time to a growing chain on a solid support, rinse away excess material, then release the finished peptide once the sequence is complete. This approach allows for high purity and precise control over the final product.
You will most often spot Dipeptide-18 in leave-on items such as serums, eye creams, anti-aging moisturizers and lightweight lotions designed to smooth or firm the look of skin. It can also appear in sheet masks or concentrated booster drops meant to layer under your usual cream.
Dipeptide-18’s Cosmetic Benefits/Uses
Dipeptide-18 is mainly added to formulas for its skin-conditioning ability, meaning it helps the surface of the skin feel softer, more even and well cared for. By supporting a smoother texture and helping maintain a healthy moisture balance, it can make the overall complexion appear fresher and more supple.
Who Can Use Dipeptide-18
Dipeptide-18 is considered gentle enough for most skin types, including dry, normal, combination and oily skin. Its lightweight nature means it will not add heaviness to oilier complexions while still offering a conditioning touch to drier areas. Sensitive skin users generally tolerate the peptide well because it lacks common irritants like fragrance or essential oils, though individual sensitivities can never be ruled out entirely.
Because Dipeptide-18 is created through laboratory synthesis, no animal-derived material is involved, making it suitable for both vegans and vegetarians.
Topical peptides like Dipeptide-18 are not known to pose special risks during pregnancy or breastfeeding. Still, this information does not replace medical advice. Anyone who is pregnant or nursing should discuss every skincare product with a qualified healthcare provider to be on the safe side.
The peptide does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Dipeptide-18 vary from person to person. The points below outline potential side effects, yet most users will not encounter them when using a well-formulated product applied as directed.
- Mild redness or warmth – temporary flushing can occur if skin is easily reactive
- Itching or tingling – a brief sensation may happen as skin adjusts to a new peptide formula
- Dry patches – rare, but possible if the rest of the formula lacks enough moisturizers for very dry skin
- Allergic contact dermatitis – an uncommon immune response that may lead to swelling, persistent itching or rash
- Interaction with strong actives – layering multiple potent treatments (for example high-strength acids or retinoids) could heighten irritation potential in sensitive users
If you notice ongoing discomfort or any visible reaction, stop using the product and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 (non-comedogenic). Dipeptide-18 is a tiny, water-soluble molecule that does not form an oily film or block pores, so it earns the lowest possible rating. This makes the peptide suitable for acne-prone or breakout-prone skin. Because the full formula, not just one ingredient, determines pore clogging potential, always consider the heavier emollients or waxes that may accompany it in a final product.
Summary
Dipeptide-18 is primarily a skin-conditioning peptide that helps skin feel smoother and better hydrated by supporting a balanced surface and refined texture. Its small size lets it sit comfortably on the skin without heaviness, offering subtle improvements in softness and suppleness.
While peptides as a category enjoy strong buzz in anti-aging circles, Dipeptide-18 itself remains a niche choice compared with superstar peptides like Matrixyl or copper peptides, yet brands seeking novel two-amino-acid chains are starting to showcase it in serums and eye creams.
Overall safety is high, with low irritation risk and a non-comedogenic profile, but as with any new cosmetic ingredient it is smart to patch test a fresh product before full-face use to rule out individual sensitivities.