What Is Dipeptide-22?
Dipeptide-22 is a lab-made peptide made of two amino acids, serine and valine. Because it is synthetic, it is not harvested from plants or animals, which helps keep the ingredient consistent from batch to batch. Peptides started gaining attention in skin care in the late 1990s when scientists saw how short chains of amino acids could signal skin cells to behave in a more youthful way. Dipeptide-22 is one of the newer additions to this family, designed to offer targeted skin benefits without the stability problems larger proteins often face.
Manufacturing begins with the separate preparation of the amino acids in a controlled setting. Using solid-phase peptide synthesis, chemists link serine to valine in a precise order, then purify the resulting dipeptide so it meets cosmetic-grade standards. The final powder is dissolved or dispersed in a suitable carrier so it can blend smoothly into finished formulas.
You will most often find Dipeptide-22 in anti-aging serums, firming creams, eye treatments, sheet masks, moisturizers and concentrated booster drops. Brands choose it for products aimed at improving skin texture and maintaining a healthy, well-conditioned appearance.
Dipeptide-22’s Cosmetic Benefits/Uses
Dipeptide-22 brings one main advantage to skin care formulas.
Skin conditioning: This peptide helps keep the skin surface soft, smooth and hydrated. By supporting the skin’s natural barrier and reinforcing a supple feel, it can enhance overall comfort, reduce the look of dryness and make the complexion appear fresher.
Who Can Use Dipeptide-22
Dipeptide-22 is generally well suited for all skin types including dry, oily, combination and sensitive because it focuses on conditioning rather than exfoliation or strong active effects. Those with extremely reactive or broken skin barriers should still approach any new ingredient carefully since even gentle peptides can sometimes feel irritating on compromised skin.
Because the peptide is made entirely in a lab without any animal-derived material, products that feature Dipeptide-22 can fit vegan and vegetarian lifestyles. No animal testing or by-products are required for its synthesis.
Current research shows no specific risks for women who are pregnant or breastfeeding, yet individual health situations vary. This content is not medical advice, so anyone expecting or nursing should have a quick conversation with a doctor before adding new skincare items that include Dipeptide-22.
The ingredient does not increase photosensitivity, so it does not make skin more susceptible to sunburn. Standard daily sun protection is still recommended for overall skin health. Dipeptide-22 also layers well with most common actives such as hyaluronic acid or niacinamide, making it easy to incorporate into an existing routine.
Potential Side Effects/Adverse Reactions
Side effects from topical Dipeptide-22 can vary between individuals. The points below outline potential reactions only; most users will not experience these issues when the ingredient is used correctly in a well-formulated product.
- Mild redness
- Temporary stinging or tingling
- Itchiness or dryness in very sensitive skin
- Rare allergic contact dermatitis
If any of these effects occur stop using the product and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Dipeptide-22 is a tiny, water-soluble molecule that does not leave an oily film on the skin or build up inside pores. It has no known tendency to trap dead cells or mix with sebum, which is why formulators classify it as non-comedogenic.
Because of this, it is considered suitable for people who are prone to acne or frequent breakouts.
The rating may vary slightly depending on the full formula it is blended into, so check the entire ingredient list if your skin is highly reactive.
Summary
Dipeptide-22 is a lab-made duo of serine and valine that conditions the skin, supports a smoother texture and helps the surface feel hydrated and supple. By signaling skin cells to maintain a healthy barrier, it boosts softness without heavy oils or waxes.
It is not yet a household name like hyaluronic acid but niche brands have started adding it to anti-aging serums, eye creams and firming lotions. As more consumers look for gentle peptides, its popularity is expected to rise.
Safety data so far shows a very low risk of irritation, allergy or pore blockage, making it a friendly option for most skin types. Still, every complexion is unique so perform a small patch test when trying any new product that lists Dipeptide-22 to be on the safe side.