What Is Dipeptide-27?
Dipeptide-27 is a lab-made peptide built from two amino acids, glycine and leucine. Because it is synthetic, manufacturers can control its purity and stability, which helps ensure consistent performance in skincare formulas. Peptides began appearing in cosmetic products in the early 2000s, when researchers discovered their ability to signal skin to perform certain functions such as producing more collagen. Dipeptide-27 joined this wave as a compact, easy-to-formulate option.
To create Dipeptide-27, chemists typically rely on solid-phase peptide synthesis. Each amino acid is added step by step to a resin bed, then carefully bonded and purified to yield a precise two-unit chain. The finished ingredient is a fine powder that dissolves well in water-based solutions and remains stable across the normal pH range found in skincare.
Thanks to its size and water solubility, Dipeptide-27 blends smoothly into lightweight serums, hydrating gels, eye creams, sheet masks and leave-on moisturizers. Brands often pair it with antioxidants, hyaluronic acid and botanical extracts in anti-aging or firming collections that target dullness, rough texture and early lines.
Dipeptide-27’s Cosmetic Benefits/Uses
Formulators turn to Dipeptide-27 mainly for what it can do on the skin’s surface.
Its key role is skin conditioning. By helping the outer layer hold on to water and feel smoother, Dipeptide-27 can improve the overall softness and suppleness of the complexion. Consistent use may leave skin looking more refined and resilient, which is why it shows up in products aimed at boosting firmness and restoring a healthy glow.
Who Can Use Dipeptide-27
Dipeptide-27 is generally considered friendly for all skin types – oily, combination, dry and even sensitive – thanks to its lightweight, water-based nature and low likelihood of clogging pores or leaving a greasy film. Those with reactive or redness-prone skin often tolerate it well because it contains no known harsh actives or exfoliants.
Because Dipeptide-27 is produced entirely in a lab rather than sourced from animals, it is suitable for both vegans and vegetarians. Cruelty-free brands typically have no issue keeping the peptide aligned with their animal-friendly standards.
Pregnant or breastfeeding women can usually use products containing this peptide, as it is applied only to the outer skin and is not known to penetrate deeply or disrupt hormones. That said, this is not medical advice and anyone who is pregnant or nursing should have a quick word with their doctor before adding new skincare just to be safe.
The ingredient does not make skin more sensitive to sunlight, so there is no special need for extra sun precautions beyond the daily SPF most dermatologists recommend anyway.
Potential Side Effects/Adverse Reactions
Responses to topical Dipeptide-27 differ from person to person. The points below outline possible effects, but most users will not experience them when the ingredient is properly formulated and used as directed.
- Mild redness or warmth shortly after application
- Temporary itching or tingling, especially on very sensitive skin
- Rare allergic contact dermatitis leading to localized rash
- Irritation caused by other actives or fragrances in the same product rather than by Dipeptide-27 itself
If any of these reactions occur, stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5
Dipeptide-27 is a tiny, water-soluble molecule that sits on the skin’s surface without blocking pores, so it earns the lowest possible comedogenic score. The ingredient contains no oils or waxes that would normally trap dead cells or excess sebum inside a pore. For this reason it is considered safe for people who are prone to acne or breakouts.
Keep in mind that the overall formula matters. If a serum or cream pairs Dipeptide-27 with heavy butters or high-level silicones, those other materials could raise the pore-clogging potential even though the peptide itself is non-comedogenic.
Summary
Dipeptide-27 is a lab-crafted two-amino-acid peptide used mainly to condition skin, leaving it feeling softer and more resilient. By boosting surface hydration and supporting the skin barrier it can subtly improve texture and the look of firmness.
While peptides as a category are well known in skincare, Dipeptide-27 remains a niche option that shows up most often in mid-range and premium anti-aging lines rather than on every drugstore shelf.
Safety-wise, the ingredient is non-comedogenic, generally non-irritating and vegan friendly. As with any new skincare product it is smart to do a quick patch test before full use to make sure your skin agrees with it.