What Is Dipeptide-28?
Dipeptide-28 is a lab-made mini protein built from two natural amino acids, serine and threonine. Because it is synthetic, manufacturers can control its purity and strength, making it reliable for skin care. Peptides began gaining attention in the 1990s when researchers found that small chains of amino acids could signal the skin to look smoother and feel firmer. Since then Dipeptide-28 has secured a spot in many modern formulas.
Creating Dipeptide-28 starts with isolating serine and threonine, then linking them together through solid-phase peptide synthesis. The finished ingredient is a fine powder that dissolves easily in water-based solutions, which helps chemists blend it into creams and serums without fuss.
You will most often see Dipeptide-28 in anti-aging moisturizers, silky serums, sheet masks and eye treatments aimed at giving the skin a refreshed look. It pairs well with hydrators like glycerin and hyaluronic acid to build products that feel light yet nourishing.
Dipeptide-28’s Cosmetic Benefits/Uses
In skin care formulas Dipeptide-28 serves one main role that brings several visible perks
Skin conditioning: By helping the skin surface stay soft and flexible, Dipeptide-28 supports a smoother feel and a healthier appearance. Formulators lean on it to boost overall comfort, add a touch of firmness and leave a satiny finish that users notice right away.
Who Can Use Dipeptide-28
Dipeptide-28 is gentle enough for most skin types including dry, normal, combination and oily skin because it conditions without leaving a heavy or greasy residue. Those with very reactive or allergy-prone skin should still watch for any unusual redness since any new peptide can occasionally trigger sensitivity.
Because the molecule is made entirely in the lab from basic amino acids and contains no animal by-products, it is suitable for both vegans and vegetarians.
No specific safety issues have been flagged for women who are pregnant or breastfeeding, yet data is limited. This information is not medical advice; expectant or nursing mothers should ask a healthcare professional before adding new products to their routine.
Dipeptide-28 does not make skin more vulnerable to sunburn, so it is not considered photosensitizing. It also plays well with most common skincare ingredients such as niacinamide, glycerin and hyaluronic acid, allowing easy inclusion in multi-step routines.
Potential Side Effects/Adverse Reactions
Responses to topical Dipeptide-28 differ from person to person. The issues listed below are only potential outcomes and are not likely for the average user when the ingredient is properly formulated.
- Mild redness or warmth
- Temporary stinging on very sensitized or broken skin
- Rare allergic contact dermatitis marked by itching or swelling
- Heightened irritation if layered immediately after strong acids or retinoids
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Dipeptide-28 is a tiny water-soluble molecule that contains no oils, waxes or heavy emollients so it does not linger in pores or create the kind of film that can trap sebum. Because of this lightweight profile it is considered a zero on the comedogenic scale and is suitable for skin that is prone to acne or frequent breakouts.
Its quick-absorbing nature also means it can be layered with common acne fighters like benzoyl peroxide or salicylic acid without increasing pore congestion.
Summary
Dipeptide-28 is a synthetic dipeptide made from serine and threonine that conditions the skin, helping it stay supple, smooth and slightly firmer. Its small size allows it to absorb fast and leave a silky finish, which is why it shows up in moisturizers, serums and eye treatments.
While it is not as famous as retinol or vitamin C, formulators appreciate its gentle yet effective touch and its popularity is steadily growing among brands that focus on lightweight anti-aging benefits.
Current research and real-world use point to a strong safety profile with minimal risk of irritation, no hormonal concerns and no photosensitivity. Even so it is smart to patch test any new product that features Dipeptide-28 to be sure your skin remains comfortable.