What Is Dipeptide-28 Nicotinate?
Dipeptide-28 Nicotinate is a lab-created compound formed when niacin, a vitamin B3 derivative, is chemically linked with Dipeptide-28, a short chain of two amino acids. By pairing a well-known skin nutrient with a targeted peptide, formulators aim to combine the soothing qualities of niacin with the signaling benefits peptides can offer. First explored in advanced anti-aging research, the ingredient gained traction once studies showed that joining niacin to peptides could improve stability and skin affinity compared with using either material alone.
Production typically starts with synthesizing Dipeptide-28 through standard peptide-bond techniques, after which niacin is activated and reacted with the peptide under controlled temperature and pH conditions. The resulting molecule is then purified, dried and milled into a fine powder ready for cosmetic use.
Today you will most often spot Dipeptide-28 Nicotinate in leave-on products where prolonged skin contact maximizes its benefits. These include serums aimed at firmness support, lightweight moisturizers geared toward dull or uneven tone, sheet masks promising a quick pick-me-up and specialized eye creams focused on smoothing texture.
Dipeptide-28 Nicotinate’s Cosmetic Benefits/Uses
Dipeptide-28 Nicotinate appears on ingredient lists primarily for one key job
Skin conditioning: By blending niacin’s ability to improve skin barrier resilience with the peptide’s potential to encourage a smoother surface, this ingredient helps maintain soft, supple skin. Formulators value it for boosting hydration retention, lending a more even appearance and supporting an overall healthy look without heaviness or grease.
Who Can Use Dipeptide-28 Nicotinate
Dipeptide-28 Nicotinate is generally considered suitable for most skin types. Its peptide base is lightweight enough for oily or combination skin while the niacin component supports barrier strength that dry or mature skin often lacks. Sensitive complexions usually tolerate the ingredient well because it is non-acidic and fragrance-free, though anyone with a known allergy to vitamin B3 or peptides should steer clear.
The compound is synthesized in a laboratory without animal-derived materials so products featuring it are normally appropriate for vegans and vegetarians. Always verify that the entire formula and manufacturing process meet your dietary or ethical standards, since other ingredients in the same product could differ.
No specific warnings link Dipeptide-28 Nicotinate to pregnancy or breastfeeding complications, yet hormonal shifts can make skin more reactive. This information is not medical advice and pregnant or nursing individuals should ask a healthcare professional before adding any new skincare product.
The ingredient does not cause photosensitivity and can be used day or night. Standard daytime sun protection is still recommended because healthy skin care practices always include shielding the skin from UV damage.
Potential Side Effects/Adverse Reactions
Responses to topical Dipeptide-28 Nicotinate vary from person to person. The following points outline potential side effects but most users experience none of them when the ingredient is formulated and applied correctly.
- Mild redness or warmth – a short-lived flush can occur in very sensitive skin due to niacin’s circulation-boosting nature
- Temporary stinging or tingling – more likely if applied to compromised or freshly exfoliated skin
- Allergic contact dermatitis – rare but possible if an individual is sensitive to peptides or vitamin B3 derivatives
- Pimples or clogged pores – unlikely yet possible in extremely acne-prone users when paired with heavier occlusive ingredients in the same formula
- Interaction-related irritation – layering with strong acids or retinoids can amplify overall skin stress and lead to dryness or peeling
Discontinue use and seek medical advice if you notice persistent discomfort swelling or an unexpected reaction.
Comedogenic Rating
Rating: 1/5
Dipeptide-28 Nicotinate is a small, water-friendly molecule that does not leave an oily film on the skin, so it is unlikely to block pores on its own. Because it lacks heavy lipids and waxes its tendency to provoke blackheads or whiteheads is minimal, earning it a low score of 1.
That makes the ingredient generally suitable for acne-prone or breakout-prone skin, provided the rest of the formula is also lightweight and non-occlusive.
Keep in mind that actual pore clogging risk depends on the full product blend and personal skin response, so even low-comedogenic ingredients can feel heavy if paired with rich butters or oils.
Summary
Dipeptide-28 Nicotinate functions mainly as a skin-conditioning agent. By merging niacin with a targeted dipeptide it helps reinforce the skin barrier, boosts surface hydration and encourages a smoother, more even look. The peptide portion signals the skin to maintain firmness while the niacin part supports healthy moisture balance, giving a lightweight yet nurturing effect.
The ingredient is still a niche addition, found mostly in higher-end serums and specialty creams rather than mainstream drugstore formulas. As research on peptide-vitamin hybrids grows its presence may increase but for now you will spot it in select products aimed at anti-aging or tone improvement.
Overall safety is high with few documented issues. Most users can apply it daily without trouble though individual sensitivities are always possible. Whenever you try a new product containing Dipeptide-28 Nicotinate it is wise to carry out a small patch test first to ensure your skin agrees with the full formula.