What Is Dipeptide-36?
Dipeptide-36 is a lab-created peptide made from two units of the amino acid serine. Because it is synthesized rather than extracted from plants or animals, its purity and consistency can be tightly controlled. The compound is produced through solid-phase peptide synthesis, a step-by-step laboratory method that links individual amino acids into precise short chains. Peptides began attracting attention in skin care in the 1990s when researchers discovered their ability to signal skin cells and support a healthier skin barrier. Dipeptide-36 emerged from this wave of innovation as formulators looked for smaller, easy-to-stabilize peptides that could enhance everyday products without requiring complicated delivery systems.
Today you are most likely to see Dipeptide-36 in lightweight leave-on items such as serums, moisturizers, eye creams, sheet masks and targeted anti-aging treatments. Its small molecular size lets it blend seamlessly with water-based formulas and remain effective at the modest concentrations common in over-the-counter cosmetics.
Dipeptide-36’s Cosmetic Benefits/Uses
Within a topical formula Dipeptide-36 serves a single yet important role.
As a skin-conditioning agent it helps the surface of the skin feel soft, smooth and supple. By supporting the skin’s natural moisturizing factors it can slightly improve hydration levels and reinforce the barrier that keeps water from evaporating too quickly. Regular use may leave the complexion looking healthier and more refreshed which is why brands often position this peptide in daily hydrators and soothing post-treatment products.
Who Can Use Dipeptide-36
Dipeptide-36 is considered gentle enough for nearly every skin type, including dry, oily and sensitive skin, because its main job is to support hydration rather than exfoliate or strip the barrier. People with known peptide allergies should avoid it, but such allergies are rare.
Because it is fully synthetic and contains no animal by-products, the ingredient is suitable for both vegans and vegetarians. Most brands that feature it also note that no animal testing was involved in its manufacture.
Current data show no specific risks for pregnant or breastfeeding women when Dipeptide-36 is used topically in normal cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should still clear every skin care item with a qualified healthcare provider to be safe.
The peptide does not make skin more sensitive to sunlight, so it is not considered a photosensitizer. Daily sunscreen is still a smart habit for overall skin health.
Dipeptide-36 plays well with common actives like niacinamide, hyaluronic acid and ceramides, which lets users layer it without worrying about ingredient conflicts.
Potential Side Effects/Adverse Reactions
Reactions to Dipeptide-36 can differ from person to person. The issues listed below are only potential side effects and most users will not experience them when the product is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary itching or stinging in very sensitive skin
- Allergic contact dermatitis presenting as a rash or hives
- Breakouts triggered by other comedogenic ingredients in the same product rather than the peptide itself
If you notice any of the above reactions stop using the product and seek guidance from a dermatologist or healthcare professional.
Comedogenic Rating
Rating: 0/5
Dipeptide-36 is water soluble and used at low levels, so it does not clog pores or trap oil under the skin. The molecule has no oily tails or waxy texture that would stick inside follicles, which is why its comedogenic score is zero.
Because of this, the ingredient is generally fine for people who are prone to acne or frequent breakouts.
As always, other ingredients in the same product can affect how pore friendly the final formula is, so check the full ingredient list if congestion is a concern.
Summary
Dipeptide-36 is a lab made two–amino-acid peptide that conditions skin by helping it hold on to water and feel smoother. It slips easily into light serums, gels and lotions, quietly boosting hydration without adding weight.
While not as famous as big-name peptides like Matrixyl or copper peptide, it shows up in a growing number of mid-range and indie skin care lines that want a simple, stable peptide to round out their formulas.
Current research points to a strong safety profile with very low irritation risk for most users. Still, skin can be unpredictable, so it is smart to patch test any new product that contains Dipeptide-36 before spreading it over a larger area.