What Is Dipeptide-37?
Dipeptide-37 is a short chain made of two amino acids, leucine and threonine. These building blocks occur naturally in the body but the version used in cosmetics is usually produced in a lab through solid-phase peptide synthesis or biotechnology fermentation. This controlled process keeps the peptide pure and stable so it can perform well in skin care. Peptides started turning heads in beauty formulas during the 1990s when brands looked for milder ways to support the skin’s surface. Dipeptide-37 is one of the newer entries on that list, valued for its gentle conditioning touch. You will most often spot it in lightweight serums, daily moisturizers, age-defying creams, eye gels, sheet masks and after-sun treatments where a soft, smooth finish is the goal.
Dipeptide-37’s Cosmetic Benefits/Uses
In topical products Dipeptide-37 is used for one primary reason.
Skin conditioning: This peptide helps the outer layer of skin feel softer, look smoother and hold on to moisture. By supporting the surface it can leave the complexion supple and refreshed which makes the rest of the formula feel more luxurious on application.
Who Can Use Dipeptide-37
Dipeptide-37 is considered friendly for most skin types including dry, normal, combination, oily and sensitive because it is lightweight and non greasy. It focuses on surface hydration so it rarely upsets reactive or acne-prone complexions. There are no known reasons for extremely dry or eczema-prone skin to avoid it, though these concerns may still need richer support alongside the peptide.
The peptide used in cosmetics is made in a lab through fermentation or solid-phase synthesis and contains no animal by-products, making it suitable for vegans and vegetarians.
Current safety data does not flag Dipeptide-37 as a risk for pregnant or breastfeeding women. Still, this information is not medical advice and anyone who is expecting or nursing should show the full ingredient list of any skincare product to a qualified health professional before use.
Dipeptide-37 is not known to cause photosensitivity, so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects from topical Dipeptide-37 differ from person to person. The points below cover potential reactions yet most users experience none of them when the ingredient is formulated and used correctly.
- Mild redness or warmth shortly after application
- Temporary itching or tingling on very sensitive skin
- Rare allergic contact dermatitis marked by persistent rash or swelling
- Stinging if applied to broken or freshly exfoliated skin
- Possible formula destabilization when mixed with highly acidic leave-on treatments which could heighten irritation
If any of these effects occur discontinue use and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 / 5
Dipeptide-37 is a small, water-soluble molecule with no heavy oils or waxes so it does not sit in pores or form a film that can trap debris. Because of this clean profile the risk of clogged pores is virtually zero.
Suitable for acne-prone or breakout-prone skin.
Its low use level in formulas, often under 1 percent, further limits any pore-blocking concern.
Summary
Dipeptide-37 is a lab-made blend of two amino acids that conditions skin. It softens, smooths and helps the surface hold moisture by supporting the barrier and attracting water. The peptide’s light feel lets it layer well under other products so you will find it in serums, moisturizers and eye treatments.
While peptides as a group are well known, Dipeptide-37 itself is still a niche pick mostly seen in mid to high-end skincare lines that focus on gentle hydration rather than bold anti-age claims.
Safety data show it is low risk for irritation, allergy or pore clogging, making it a reliable option for most people. As with any new skincare ingredient it is smart to patch test a product before full use just to be sure your skin agrees with it.