What Is Disodium Tetrahydroxy Ethyldisulfate?
Disodium Tetrahydroxy Ethyldisulfate is a salt that comes from combining sulfuric acid derivatives with sodium. Chemically it is known as 1,1,1,2,2,2-ethanehexol 1,2-bis(hydrogen sulfate) disodium salt. In simpler terms it is a small molecule that carries two sulfate groups balanced by two sodium ions, which helps it dissolve well in water-based formulas.
The ingredient first showed up in industrial cleaning solutions because of its ability to curb the growth of microbes. Formulators later noticed that the same property could help keep water-rich beauty products fresh and stable, so it made the jump to the cosmetic world in the early 2000s.
Manufacturing starts with ethanehexol, a sugar-alcohol-like compound. It is reacted with sulfur trioxide to attach the sulfate groups, then neutralized with sodium hydroxide. The result is a fine white powder or clear concentrated liquid that is easy to measure and add during the cool-down phase of production.
You will most often spot Disodium Tetrahydroxy Ethyldisulfate in lotions, gels, sheet masks, watery essences and any formula that has a high percentage of water such as toners and micellar cleansers. It is rarely highlighted on the front label but plays a quiet yet important role in keeping those products safe for daily use.
Disodium Tetrahydroxy Ethyldisulfate’s Cosmetic Benefits/Uses
In personal care products this ingredient has one key job. As an antimicrobial agent it limits the growth of bacteria, yeast and mold inside the bottle or jar. By controlling microbes it helps extend shelf life, keeps textures and scents stable and protects the user from contamination that could cause skin irritation or spoil the formula before its time.
Who Can Use Disodium Tetrahydroxy Ethyldisulfate
This preservative is considered gentle enough for all skin types including dry, oily, combination and sensitive skin because it stays on the surface and is used at very low levels. People with very reactive or allergy-prone skin who struggle with most preservatives may still want to keep an eye on how their skin feels but, in general, it is viewed as low risk.
The compound is made by reacting plant-derived or synthetic building blocks with mineral salts and no animal-based materials are involved, so products that rely on it instead of animal origin preservatives are usually suitable for vegans and vegetarians.
No specific warnings exist for pregnant or breastfeeding women. Current safety reviews have not flagged it as a hormone disruptor or high-risk ingredient. Still, this is not medical advice and anyone expecting or nursing should double-check any skincare routine with a qualified healthcare provider.
Disodium Tetrahydroxy Ethyldisulfate does not make skin more prone to sunburn and it does not interfere with sunscreen filters, so photosensitivity is not a concern.
Potential Side Effects/Adverse Reactions
Responses to any cosmetic ingredient can differ from person to person. The points below list potential side effects that have been reported in rare cases. When used correctly by the manufacturer most users will not notice any of these problems.
- Mild stinging or burning on very sensitive or freshly exfoliated skin
- Transient redness or itching, usually clearing once the product is rinsed or discontinued
- Allergic contact dermatitis in individuals already sensitized to sulfate or sodium salts
- Eye irritation if the product accidentally gets into the eyes before rinsing
If you notice any of these reactions stop using the product and seek advice from a healthcare professional if symptoms persist.
Comedogenic Rating
Rating: 0
Disodium Tetrahydroxy Ethyldisulfate is a small, highly water-soluble salt that does not form oily films on the skin and is used at very low concentrations. Because it rinses away easily and lacks any occlusive or greasy properties, it earns a solid non-comedogenic score.
Suitable for acne-prone or breakout-prone skin.
No known data suggest that it clogs pores even when layered with other ingredients, though the overall formula still matters.
Summary
Disodium Tetrahydroxy Ethyldisulfate works as an antimicrobial preservative, keeping lotions, gels, toners and similar water-rich products free from bacteria, yeast and mold. It does this by disrupting microbial cell functions while staying gentle on skin thanks to its water-soluble, low-use-level profile.
It remains a behind-the-scenes ingredient rather than a trending buzzword, so you will rarely see it highlighted on front labels even though it features in a fair number of modern formulas.
Current safety reviews rate it low risk for irritation or hormonal activity, and it carries a non-comedogenic profile that suits all skin types. As with any new skincare product, patch testing is a smart step to confirm personal compatibility.