Disodium Ubiquinone: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Disodium Ubiquinone?

Disodium Ubiquinone is the disodium salt form of ubiquinone, better known to many as coenzyme Q10. By changing ubiquinone into a salt, chemists make it dissolve more easily in water based formulas, which helps it blend smoothly into creams, gels and lotions. Most commercial supplies start with ubiquinone produced by yeast fermentation or plant based extraction. The raw ubiquinone is purified, then reacted with a controlled amount of sodium hydroxide to create the disodium salt. This extra step boosts its stability and lets it disperse evenly without the grainy feel pure coenzyme Q10 can sometimes leave.

Cosmetic chemists first took notice of ubiquinone in the 1970s when skin care research showed its role in helping cells manage energy and fend off free radicals. Turning it into disodium ubiquinone came later as brands looked for a version that stayed potent longer and was easier to formulate. Today you will spot it in anti aging serums, daily moisturizers, rich night creams, brightening masks, leave in hair treatments and even some soothing after sun gels. Anywhere a product promises to fight dullness or dryness, there is a good chance disodium ubiquinone is lending a hand.

Disodium Ubiquinone’s Cosmetic Benefits/Uses

Brands lean on this multitasker for several reasons

  • Antioxidant – Helps neutralize free radicals created by UV light and pollution which can otherwise speed up wrinkles and uneven tone
  • Hair conditioning – Smooths the cuticle so strands look shinier feel softer and resist breakage
  • Humectant – Draws in water from the air or deeper skin layers keeping the surface comfortably hydrated
  • Skin conditioning – Leaves skin feeling supple and looking refreshed by supporting its natural protective barrier
  • Skin protecting – Forms a light shield that helps guard against environmental stress making it a useful add on in day creams and sunscreens

Who Can Use Disodium Ubiquinone

This ingredient suits nearly every skin type including dry, normal, combination, oily and even sensitive because it is generally non irritating and lightweight. Those with extremely reactive or allergy prone skin should still watch for any added fragrances or solvents in the finished product rather than the active itself.

Most commercial supplies are produced by fermenting yeast or extracting from plant sources, so the raw material is usually free from animal derivatives. That makes it a vegan and vegetarian friendly option provided the final formula avoids animal based additives such as beeswax or collagen.

No specific warnings link topical disodium ubiquinone to pregnancy or breastfeeding concerns. It does not penetrate deeply or enter the bloodstream in meaningful amounts, yet this is not medical advice. Anyone pregnant or nursing should have their doctor review any skincare product to stay on the safe side.

The molecule does not heighten photosensitivity, so it will not make skin more prone to sunburn. Regular sun protection is still advised because UV light remains a leading cause of free radical damage, the very issue this ingredient helps fight.

Potential Side Effects/Adverse Reactions

Individual responses to topical disodium ubiquinone can vary. The points below list potential side effects that could occur, though most users will never experience them when the ingredient is properly formulated and used as directed.

  • Mild redness or flushing
  • Transient stinging upon application on compromised skin
  • Contact dermatitis in those with a specific sensitivity to ubiquinone or the sodium salts
  • Yellow staining on very light fabrics if a richly tinted formula is not fully absorbed before dressing
  • Possible interaction with high strength chemical exfoliants or prescription retinoids leading to cumulative irritation

If any undesirable reaction develops stop using the product and seek advice from a qualified healthcare professional

Comedogenic Rating

Rating: 0–1/5

Disodium Ubiquinone is highly water soluble, used at low levels and leaves no occlusive residue so it is very unlikely to block pores. Its tiny presence in formulas provides antioxidant support without the heavy emollient load that usually raises comedogenicity scores.

Most acne prone users should find it perfectly suitable.

Keep in mind the overall product matters more than the single ingredient—if it sits in a thick butter or wax base the finished item could still trigger breakouts.

Summary

Disodium Ubiquinone delivers antioxidant defense, moisture binding humectancy, gentle conditioning for skin and hair and a light protective veil against everyday stress. It does this by quickly neutralizing free radicals, attracting water to the surface layers and reinforcing the skin barrier so texture appears smoother and hair looks shinier.

While not yet a household name like retinol or vitamin C it is turning up in more anti aging serums, daily lotions, sunscreens and leave in conditioners as brands look for stable versions of coenzyme Q10.

Topical use is considered very safe with a low risk of irritation or pore clogging. As with any new cosmetic though a quick patch test before full-face use is the smartest way to make sure your skin agrees.

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