What Is Endonuclease V?
Endonuclease V, sometimes written as Den V, is a repair enzyme first discovered in certain bacteria where it helps fix damaged DNA. Scientists learned that the same knack for identifying and cutting out flawed DNA could also benefit skin exposed to everyday stress like sunlight and pollution. In cosmetics the ingredient is produced through fermentation: a safe laboratory process where friendly bacteria are grown in tanks, encouraged to make the enzyme then filtered away leaving a purified protein. It is blended into formulas such as leave-on serums, sheet masks, daily moisturizers and after-sun lotions, often paired with soothing agents and antioxidants.
Endonuclease V’s Cosmetic Benefits/Uses
This ingredient is valued for its skin protecting role. By supporting the skin’s natural repair steps it helps reduce the look of damage from UV rays and environmental stress, which can translate into a brighter, healthier-looking complexion over time.
Who Can Use Endonuclease V
Endonuclease V is generally considered suitable for all major skin types including dry, oily, combination and sensitive skin because it focuses on supporting repair rather than stripping or clogging. Those with highly reactive or allergy-prone skin may still want to check ingredient lists for other triggers in the finished product, as the enzyme itself is not known to be sensitizing.
The enzyme is produced through microbial fermentation so it does not rely on animal sources, making it appropriate for vegans and vegetarians.
Current research shows no specific concerns for pregnant or breastfeeding users when the enzyme is applied topically in cosmetic concentrations. This is not medical advice and anyone who is pregnant or nursing should review new skincare with a qualified healthcare provider to be on the safe side.
Endonuclease V does not induce photosensitivity and can be used morning or night without increasing sun vulnerability. Standard daytime sun protection is still recommended to protect the skin from UV stress.
Potential Side Effects/Adverse Reactions
Individual responses to topical Endonuclease V can vary. The following points outline potential side effects that could occur, though they are uncommon when the ingredient is formulated and used correctly and most people will not notice any problems.
- Mild transient redness or warmth
- Itching or tingling during the first few uses
- Localized rash or hives signaling an allergic response
- Swelling or puffiness if the skin mounts a stronger immune reaction to the protein
If any of these effects appear and persist stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Endonuclease V is a water-soluble enzyme with no oily or waxy constituents so it does not sit in pores or form films that trap debris. Formulators typically include it at low percentages, further reducing any clogging potential. Because of this it is considered non-comedogenic and is generally fine for skin that is prone to acne or breakouts. If a finished product containing Endonuclease V does cause congestion it is more likely due to other ingredients in the formula rather than the enzyme itself.
Summary
Endonuclease V is a fermentation-derived repair enzyme that helps protect skin by supporting its natural DNA repair processes after everyday exposure to sunlight and pollution. This protective role can translate into a brighter, healthier-looking complexion over time.
Although it delivers meaningful benefits, Endonuclease V is still a niche ingredient mostly found in targeted serums after-sun products and a handful of high-tech moisturizers. Its safety profile is strong with low irritation and no comedogenicity, making it suitable for a wide range of skin types. As with any new skincare product a quick patch test is smart before full application just to be on the safe side.