Epiphyllum Oxypetalum Callus Extract: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Epiphyllum Oxypetalum Callus Extract?

Epiphyllum Oxypetalum Callus Extract comes from the night-blooming cereus, a cactus prized for its large white flowers that open after sunset. Instead of harvesting the wild plant, labs take a few cells from the stem or leaf, place them in a sterile nutrient solution and let them grow into a soft mass called a callus. This callus is then filtered and processed to yield a water-based extract rich in natural sugars, amino acids and trace antioxidants that help bind moisture. The use of plant cell culture became popular in the early 2000s as a way to get consistent, high-quality plant actives without harming ecosystems, and this cactus extract followed that trend. Today the ingredient appears in hydrating serums, light lotions, anti-aging creams, sheet masks and soothing after-sun products.

Epiphyllum Oxypetalum Callus Extract’s Cosmetic Benefits/Uses

Formulators reach for this cactus extract because it tackles two core needs at once

  • Humectant – Its natural sugars draw water from the air into the upper layers of skin, giving products a quick plumping effect and helping prevent dryness through the day
  • Skin Conditioning – The blend of amino acids and antioxidants supports a smoother feel, helps calm minor redness and leaves skin softer to the touch over time

Who Can Use Epiphyllum Oxypetalum Callus Extract

This cactus extract is gentle enough for nearly every skin type. Because it is water based and non-oily it works well for oily and combination skin while its strong moisture-binding action makes it a welcome boost for dry or mature skin. Sensitive skin also tends to tolerate it because it lacks harsh acids or fragrances. There are no known concerns for darker skin tones or skin prone to hyperpigmentation.

The ingredient is grown in a plant cell culture with no animal-derived additives so it meets vegan and vegetarian standards. Many brands that use it also label their finished formulas as cruelty free.

No published data link Epiphyllum Oxypetalum Callus Extract to problems during pregnancy or while nursing. That said this information is not medical advice and anyone who is pregnant or breastfeeding should show the full ingredient list of any product to a qualified doctor before use.

The extract does not make skin more sensitive to sunlight so there is no extra need for daytime sun avoidance beyond normal sunscreen use.

Potential Side Effects/Adverse Reactions

Response to any cosmetic ingredient can vary from person to person. The points below list potential side effects that have been reported in rare cases. When used in properly formulated products most people will not notice any of these problems.

  • Mild redness or flushing
  • Rare allergic contact dermatitis in individuals sensitive to cactus family plants
  • Eye irritation if the product accidentally gets into the eyes

If you notice any persistent discomfort stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Epiphyllum Oxypetalum Callus Extract is a water based ingredient that contains mainly small humectant sugars and amino acids rather than heavy oils or waxes that can clog pores. It sits on the skin lightly, absorbs quickly and does not form an occlusive film, so it has virtually no tendency to trap sebum or debris inside follicles.

Suitable for acne-prone or breakout-prone skin.

Only the finished formula counts for pore safety, so if the extract appears in a product loaded with rich butters or silicones the overall comedogenic feel could be higher even though the extract itself is not a culprit.

Summary

Epiphyllum Oxypetalum Callus Extract acts as a humectant and skin-conditioning agent. Its natural sugars pull atmospheric moisture toward the skin surface while the amino acids and trace antioxidants help smooth texture and calm minor redness. These benefits make it useful in hydrating serums, refreshing mists, after-sun gels and daily moisturizers.

The ingredient enjoys moderate popularity: you will see it more often in niche K-beauty or eco-conscious lines than on every drugstore shelf, but its gentle performance has gained steady interest among formulators looking for plant cell culture actives.

Safety data and user reports show a very low irritation risk and no known long-term hazards. Still, every skin is unique so perform a quick patch test when you try a new product featuring this extract to confirm compatibility.

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