What Is Galloyl Sh-Hexapeptide-4?
Galloyl Sh-Hexapeptide-4 is a lab-crafted ingredient formed when gallic acid, a plant-derived antioxidant, is chemically bonded to Sh-Hexapeptide-4, a short chain of six amino acids already known for skin care benefits. This coupling merges the natural protective strength of gallic acid with the skin-friendly properties of the peptide, creating a single molecule that is both stable and effective for topical use.
The idea of linking antioxidants to peptides gained traction in the early 2000s as formulators looked for multitasking ingredients that could fit into lighter, modern textures. Galloyl Sh-Hexapeptide-4 emerged from this trend after researchers discovered that attaching gallic acid to the peptide boosted its ability to fight free radicals while keeping the peptide portion intact.
Production begins with fermenting or synthesizing the hexapeptide, then reacting it with purified gallic acid under controlled conditions so the two molecules join at specific points. The final material is filtered, tested for purity and standardized for cosmetic use.
You will most often see Galloyl Sh-Hexapeptide-4 in leave-on products where prolonged contact helps it perform: anti-aging serums, daily moisturizers, lightweight lotions, sheet masks, eye creams and recovery treatments aimed at stressed or environmentally exposed skin.
Galloyl Sh-Hexapeptide-4’s Cosmetic Benefits/Uses
This ingredient offers two main actions that make it popular with formulators
- Antioxidant: Neutralizes free radicals generated by UV light and pollution, helping slow the look of premature aging such as fine lines and uneven tone. Its dual nature means both the gallic acid and the peptide parts contribute to this protective shield
- Skin protecting: Supports the skin barrier by reducing oxidative stress and helping maintain a smoother more resilient surface, which can translate to less visible redness and improved comfort over time
Who Can Use Galloyl Sh-Hexapeptide-4
This peptide–antioxidant hybrid is generally well tolerated by all major skin types including dry, normal, combination, oily and sensitive since it is designed to be both lightweight and non-sensitizing. Its soothing antioxidant action can even be helpful for easily reactive or redness-prone complexions. There are no known reasons to avoid it based on skin tone or gender.
Because the peptide portion is produced through synthetic fermentation and the gallic acid can be sourced from plants such as oak galls or green tea, Galloyl Sh-Hexapeptide-4 is suitable for both vegetarians and vegans provided the finished product is certified cruelty free by the brand.
No published data link this ingredient to problems in pregnancy or while breastfeeding. Topical peptides have very low systemic absorption, and gallic acid is common in foods. Still, this is not medical advice and anyone who is pregnant or nursing should ask their healthcare provider before adding new skin care products.
The molecule is an antioxidant so it does not create photosensitivity. In fact it can add another layer of protection when paired with sunscreen. It also plays nicely with most other actives such as niacinamide, hyaluronic acid or gentle exfoliating acids, making it easy to slot into morning or evening routines.
Potential Side Effects/Adverse Reactions
Side effects from topical Galloyl Sh-Hexapeptide-4 vary from person to person. The points below list potential reactions but they are uncommon when the ingredient is properly formulated and used as directed.
- Mild transient stinging especially on compromised or freshly exfoliated skin
- Temporary redness or warmth in very sensitive users
- Localized irritation if combined with highly acidic products that destabilize the peptide
- Contact dermatitis in individuals allergic to gallic derivatives or specific preservatives in the finished formula
- Watery eyes or slight puffiness if applied too close to the lash line
If any discomfort, rash or persistent irritation occurs stop using the product and seek guidance from a qualified healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Galloyl Sh-Hexapeptide-4 is water soluble and used at low concentrations, so it does not leave an occlusive film that could block pores. It lacks heavy oils, waxes or fatty alcohols that typically raise comedogenicity scores, which is why it earns a 0 on the 0-5 scale.
This makes the ingredient suitable for acne-prone or breakout-prone skin.
Keep in mind the finished product’s overall formula matters. If the peptide is blended into a rich cream packed with comedogenic oils the final product could still clog pores.
Summary
Galloyl Sh-Hexapeptide-4 works as an antioxidant and skin-protecting agent. The gallic acid portion scavenges free radicals while the hexapeptide supports surface repair and comfort, creating a two-pronged defense that helps skin look smoother and more resilient.
It is still a niche ingredient compared with classics like vitamin C or niacinamide, yet its multitasking profile is drawing interest from brands aiming for lightweight high-performance formulas.
Current safety data show very low risk of irritation or sensitization when used as directed. As with any new skincare addition you should perform a patch test to confirm personal tolerance before applying a full face of a product containing this peptide.