Glycereth-12: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Glycereth-12?

Glycereth-12 is a liquid ingredient made by linking glycerin, a natural component found in vegetable oils, with ethylene oxide. The result is a clear water loving molecule that can pull in and hold moisture. First developed when chemists looked for ways to boost glycerin’s skin friendly qualities in the 1970s, Glycereth-12 soon found a place in personal care labs for its gentle feel and ease of use. Production starts with plant based glycerin that reacts with controlled amounts of ethylene oxide under heat and pressure, creating a chain of roughly 12 repeating units, hence the “12” in its name.

You are most likely to spot Glycereth-12 in lightweight moisturizers, hydrating serums, sheet masks, leave on conditioners, cleansing gels and soothing after sun products. Its ability to improve texture makes it handy in lotions and creams that need to feel silky but never greasy.

Glycereth-12’s Cosmetic Benefits/Uses

When added to a formula Glycereth-12 plays two key roles

  • Humectant – draws water from the air and from deeper skin layers to the surface, helping skin feel soft plump and refreshed while reducing tightness
  • Viscosity controlling – fine tunes thickness so products spread evenly and stay stable, giving lotions a smooth glide and keeping clear gels from running off the skin

Who Can Use Glycereth-12

Glycereth-12 is gentle enough for most skin types. Oily and acne-prone skin appreciate its weightless hydration that will not leave a film while dry and mature skin like the extra water it pulls in but may still need a richer cream on top to lock that water in. Sensitive skin usually tolerates it well because it has a low chance of causing irritation. There are no groups of skin types that must avoid it outright, though anyone with a known sensitivity to glycerin derivatives should be cautious.

Because the starting glycerin comes from vegetable oils and no animal-derived compounds are added, Glycereth-12 is considered suitable for vegans and vegetarians. The conversion step with ethylene oxide is a petrochemical process, yet this does not introduce any animal content.

Current safety data show no special restrictions for people who are pregnant or breastfeeding. The molecule stays mainly on the surface and is not known to interfere with hormones. This is not medical advice and anyone who is expecting or nursing should still ask a doctor before adding new skincare products just to be safe.

Glycereth-12 does not make skin more sensitive to the sun so it is fine for use during the day. It also plays nicely with most other common cosmetic ingredients, from acids and retinoids to botanical extracts.

Potential Side Effects/Adverse Reactions

Side effects from topical Glycereth-12 differ from person to person. The points below cover potential reactions yet they are uncommon when the ingredient is used at normal levels in well-made products.

  • Mild redness or warmth a temporary flush can occur on very reactive skin
  • Stinging on broken or freshly exfoliated skin the humectant action can create a brief tingling sensation
  • Contact dermatitis rare allergy can lead to itching or small bumps
  • Increased penetration of other actives its water binding nature can slightly boost how quickly strong ingredients like AHAs enter the skin which may raise irritation risk from those actives not from Glycereth-12 itself

If any irritation or discomfort appears stop using the product and consult a healthcare professional if symptoms persist.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Glycereth-12 is highly water soluble and leaves no occlusive film so it does not trap oil or dead cells inside pores. It has a lower molecular weight than many plant butters or waxes and quickly absorbs into the upper layers of skin then rinses away easily, all of which keeps the risk of clogged pores virtually zero. Because of this, people who are prone to acne or breakouts can generally use products containing Glycereth-12 without extra worry.

Worth noting: in most formulas Glycereth-12 is used at low levels, often under 5%, and is combined with light textures like gels or fluid lotions, further reducing any pore-clogging chance.

Summary

Glycereth-12 works mainly as a humectant and a viscosity controller. It attracts water to the skin’s surface, leaving it feeling plump and refreshed, while also fine tuning product thickness so creams glide on smoothly and gels stay clear.

This ingredient is not as famous as hyaluronic acid yet it shows up quietly in many modern moisturizers, serums and hair conditioners because chemists value its reliable performance, neutral scent and friendly texture.

Current data show it is safe for all skin types with very low irritation or comedogenic risk. Still, skin can be unpredictable so it is wise to patch test any new product containing Glycereth-12 before using it on larger areas.

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