Glyceryl Diisopalmitate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Glyceryl Diisopalmitate?

Glyceryl Diisopalmitate is a double ester made from glycerin and isopalmitic acid, a fatty acid derived from palm or coconut oil. Chemically it belongs to the larger family of glycerides that are valued for their skin-softening properties. The cosmetic industry began exploring fatty acid esters like this one in the mid-20th century when formulators sought plant-based alternatives to mineral oils. Today the ingredient is produced by heating glycerin with isopalmitic acid in the presence of a catalyst, a process called esterification. The result is a waxy, skin-friendly material that melts near body temperature and blends well with oils and butters. You will most often find Glyceryl Diisopalmitate in nourishing masks, anti-aging creams, rich moisturizers, lip balms and body butters where it lends a velvety finish and helps bind the formula together.

Glyceryl Diisopalmitate’s Cosmetic Benefits/Uses

In skin care formulas Glyceryl Diisopalmitate acts primarily as an emollient, meaning it softens and smooths the skin surface. By filling in tiny gaps between skin cells it creates a light, occlusive layer that slows water loss, boosts comfort and leaves the complexion feeling supple without a greasy residue.

Who Can Use Glyceryl Diisopalmitate

Thanks to its mild nature Glyceryl Diisopalmitate is generally well tolerated by dry, normal and combination skin. Very oily or highly acne-prone complexions might find rich formulas that contain large amounts of this fatty ester a bit heavy, though the risk of clogged pores is still low compared with heavier plant butters.

The ingredient is normally produced from vegetable glycerin and plant-derived isopalmitic acid, so it is suitable for vegans and vegetarians provided the finished product is certified to use only plant sources.

No data indicate that topical Glyceryl Diisopalmitate poses a risk to pregnant or breastfeeding women. That said this is not medical advice and anyone who is expecting or nursing should show any personal care product to a qualified doctor just to be safe.

The ester does not increase photosensitivity and can be used day or night without extra sun precautions beyond your usual SPF habit. It also plays nicely with most other cosmetic ingredients so formulating conflicts are rare.

Potential Side Effects/Adverse Reactions

Individual responses to Glyceryl Diisopalmitate can differ. The points below outline uncommon but possible reactions. Assuming the product has been formulated and preserved correctly most users will not run into problems.

  • Mild skin irritation such as redness or itching in sensitive individuals
  • Rare allergic contact dermatitis for those with a specific fatty acid or glyceride allergy
  • Occasional pore congestion or breakouts if used in very high concentrations on oily skin
  • Eye discomfort if the raw material is accidentally rubbed into the eyes

If you notice persistent irritation or any unexpected reaction stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1/5

Glyceryl Diisopalmitate is a lightweight fatty ester that melts close to body temperature so it spreads thinly rather than building up inside pores. Compared with heavier plant butters its molecular size and semi-fluid texture give it a much lower tendency to trap dead cells or sebum which is why it earns a rating of 1. Only when used in very rich formulations or applied in thick layers might it contribute to minor congestion.

Most people who are prone to acne or breakouts can use products containing this ingredient without trouble although those with extremely oily skin may still prefer ultra-light options.

Remember that comedogenicity depends on the whole formula. When blended with quick-drying oils or volatile silicones the risk stays low while pairing it with heavy waxes can nudge the rating upward.

Summary

Glyceryl Diisopalmitate acts chiefly as an emollient that smooths skin fills tiny surface cracks and slows moisture loss to keep the complexion soft and comfortable. Its waxy yet melt-in texture also stabilizes creams and balms giving them a velvety finish and helping pigments glide more evenly.

While not as famous as hyaluronic acid or shea butter it maintains a quiet popularity among formulators who want a plant-derived alternative to mineral oils without a greasy feel.

Overall it is considered safe with very low rates of irritation or allergy. Still it is wise to patch test any new product containing Glyceryl Diisopalmitate especially if your skin is sensitive so you can be sure it agrees with you.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search