Hexaacetyl Myricetin: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hexaacetyl Myricetin?

Hexaacetyl Myricetin is a lab-modified version of the natural flavonoid myricetin, which is found in berries, tea, and certain tree bark. Through a process called acetylation, six acetate groups are added to the original molecule, making it more oil friendly and stable for use on skin. Chemists typically produce it by reacting purified myricetin with acetic anhydride under controlled conditions, followed by filtration and drying to yield a fine, off-white powder.

Interest in this ingredient grew as researchers looked for gentler plant-derived compounds that could improve skin feel. Its enhanced stability compared with raw myricetin opened the door for formulators to add it to a broader range of products. Today you will find Hexaacetyl Myricetin in items such as lightweight serums, anti-aging creams, sheet masks, eye-area treatments and after-sun lotions, where a smooth non-greasy finish is desired.

Hexaacetyl Myricetin’s Cosmetic Benefits/Uses

In skin care formulas Hexaacetyl Myricetin serves mainly as a skin-conditioning agent, meaning it helps keep the surface of the skin soft, supple and comfortable. Its structure allows it to form a light, breathable layer that reduces moisture loss while giving products a silky glide, which can improve the overall application experience.

Who Can Use Hexaacetyl Myricetin

Thanks to its lightweight oil compatible structure Hexaacetyl Myricetin suits most skin types including dry, normal, combination, oily and sensitive skin. It adds slip and softness without clogging pores so even acne-prone users can usually tolerate it. Those with extremely reactive or allergy-prone skin should keep an eye out for any flavonoid sensitivities but serious issues are uncommon.

The ingredient is made from plant sourced myricetin and the acetylation process does not involve animal derivatives, making it appropriate for vegans and vegetarians.

No specific warnings exist for pregnant or breastfeeding women regarding topical Hexaacetyl Myricetin. That said this is not medical advice and anyone expecting or nursing should show their skincare routine to a qualified health professional to be safe.

Current data does not link Hexaacetyl Myricetin to photosensitivity. It neither increases sun burn risk nor requires special UV precautions beyond the daily sunscreen already recommended.

Potential Side Effects/Adverse Reactions

Reactions to topical Hexaacetyl Myricetin differ from person to person. The points below list possible but unlikely outcomes when the ingredient is used in properly formulated products.

  • Mild redness or warmth shortly after application
  • Temporary itching or tingling in highly sensitive individuals
  • Contact dermatitis in users allergic to flavonoids or acetate groups
  • Watery eyes or irritation if the product migrates into the eye area
  • Interaction with other potent actives that could heighten overall skin sensitivity

If any discomfort or persistent reaction occurs stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1 / 5

Hexaacetyl Myricetin is largely non greasy and sits as a thin breathable film that lets sebum escape rather than trapping it inside follicles. It is also used at low concentrations, which further lowers any clogging risk. Because of this the ingredient is generally suitable for people who are prone to acne or breakouts.

No reports suggest that it exacerbates blackheads or whiteheads, and it does not contain heavy waxes or butters that normally raise a formula’s comedogenic score.

Summary

Hexaacetyl Myricetin is a lab-enhanced form of the plant flavonoid myricetin that mainly acts as a skin-conditioning agent. By adding six acetate groups chemists make the molecule more oil friendly and stable so it can create a light silky layer on the skin that reduces moisture loss and improves product spreadability.

While not as famous as hyaluronic acid or niacinamide the ingredient is slowly gaining traction in niche serums and eye creams where a smooth elegant after-feel is prized.

Available safety data shows a low risk of irritation or pore clogging for most users. Even so it is smart to patch test any new product containing Hexaacetyl Myricetin to ensure your skin responds well.

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