Hexyldecyl Ester Of Hydrolyzed Collagen: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 27, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Hexyldecyl Ester Of Hydrolyzed Collagen?

Hexyldecyl Ester Of Hydrolyzed Collagen is a specialty ingredient created by linking small fragments of collagen, known as hydrolyzed collagen, to a fatty alcohol called 2-hexyldecanol. The collagen portion usually originates from bovine or marine sources that have been cleaned, purified and broken down into peptides, while the fatty alcohol is synthesized from plant oils. Combining the two gives a molecule that offers the feel-good properties of collagen along with the spreadability and softness provided by the lipid chain.

Collagen derivatives first appeared in skin care in the 1950s as chemists looked for ways to mimic the skin’s own supportive proteins. Early versions were water loving and stayed on the surface. By the late 1990s formulators discovered that attaching fatty chains improved compatibility with both skin and hair, leading to esters such as Hexyldecyl Ester Of Hydrolyzed Collagen. Today the ingredient is produced through a controlled esterification process where hydrolyzed collagen peptides react with 2-hexyldecanol under mild heat and vacuum, followed by filtration and drying to yield a soft, waxy material.

Because it balances protein-like benefits with an emollient feel, you will most often find Hexyldecyl Ester Of Hydrolyzed Collagen in moisturizers, anti-aging creams, leave-on hair conditioners, rinse-off masks, styling creams and nourishing body lotions.

Hexyldecyl Ester Of Hydrolyzed Collagen’s Cosmetic Benefits/Uses

This ingredient is prized for its dual conditioning abilities that enhance both skin and hair formulas.

  • Hair Conditioning: Forms a light, flexible film on hair strands that smooths the cuticle, reduces static and improves combability. The fatty portion adds slip and softness while the collagen peptides help hair retain moisture for a healthier look.
  • Skin Conditioning: Deposits a breathable layer on the skin that traps water, improves softness and gives a silky afterfeel. The peptide side may support the skin’s natural barrier, and the lipid side adds a subtle emollient glow without greasiness.

Who Can Use Hexyldecyl Ester Of Hydrolyzed Collagen

Thanks to its light film-forming nature and balanced moisture, this ingredient is generally well suited for normal, dry and combination skin types. Oily and acne-prone users can often use it too since it does not feel greasy, but they may prefer lower concentrations to avoid a heavy finish.

People following vegan or vegetarian lifestyles should be aware that the collagen portion is typically sourced from animals such as fish or cattle, so formulas containing this ester are not considered vegan friendly unless the label specifically states a plant-based or bio-engineered collagen source.

Pregnant and breastfeeding individuals can usually use products containing Hexyldecyl Ester Of Hydrolyzed Collagen because the molecule is too large to enter the bloodstream in any meaningful amount. That said, this is not medical advice and anyone who is expecting or nursing should review all personal care products with a qualified healthcare provider.

The ingredient does not increase sensitivity to sunlight, so it will not make skin more prone to sunburn. As with most conditioners, it rinses off cleanly and leaves no residue that attracts UV light.

Potential Side Effects/Adverse Reactions

Reactions to topical Hexyldecyl Ester Of Hydrolyzed Collagen vary from person to person. The effects listed below are possible yet uncommon when the ingredient is properly formulated.

  • Mild redness or irritation in very sensitive skin
  • Temporary stinging if applied to broken or freshly exfoliated skin
  • Rare allergic response due to the animal-derived collagen peptides
  • Build-up on fine hair leading to limp feel when used in heavy leave-in products

If you experience any of these effects stop using the product and consult a healthcare professional if symptoms persist.

Comedogenic Rating

Rating: 1/5

Hexyldecyl Ester Of Hydrolyzed Collagen is an esterified protein fragment rather than a pure oil so it sits lightly on the skin and is unlikely to clog pores. Its fatty chain improves spreadability yet washes away easily, which keeps residue to a minimum. For these reasons it earns a low score of 1.

Most people prone to acne or breakouts can use products containing this ingredient without major concern, especially when it appears lower on the label.

Because formulas vary, the overall comedogenicity of the finished product will depend on the other ingredients paired with the ester.

Summary

Hexyldecyl Ester Of Hydrolyzed Collagen conditions skin and hair by forming a light film that locks in moisture, smooths texture and lends a soft silky feel. The collagen peptide side reinforces the surface while the fatty side supplies slip and emollience.

It is a niche ingredient found mostly in mid to high end moisturizers, leave-in conditioners and anti-aging creams rather than in mass-market products, yet formulators value it for its balanced performance.

Overall safety is high with only rare reports of irritation or allergy tied to its animal-derived collagen source. As with any new cosmetic it is wise to patch test before full use to ensure personal compatibility.

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